Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UKT5 / FBX4_HUMAN
Protein Name F-box only protein 4
Gene Name Name: FBXO4
Synonyms:FBX4;
Organism Homo sapiens (Human)

PRO ID PR:Q9UKT5
DAG View
PRO Name F-box only protein 4 (human)
Definition An F-box only protein 4 that is encoded in the genome of human.
Short Label hFBXO4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UKT5 (FBXO4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
T10 Phosphorylation PhosphoSitePlus
S12 Phosphorylation P49841 (GSK3B) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 21242966, 15302935, ...19690332, 24275569, 18598945
S37 Phosphorylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus   UniProt 23186163
R144 Methylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
T240 Phosphorylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
Y343 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation HPRD 17322306, 20058876
S12 Phosphorylation HPRD   PRO 19413330, 19651622, 21242966, ...18767875, 20058876, 17322306, 18598945
S48 Phosphorylation HPRD 18767875
S238 Phosphorylation HPRD 17924679
T239 Phosphorylation HPRD 17924679
T240 Phosphorylation HPRD 19413330, 17924679
Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation HPRD 17322306, 20058876
S12 Phosphorylation HPRD 17322306, 18767875, 19413330, ...19651622, 20058876
S48 Phosphorylation HPRD 18767875
S238 Phosphorylation HPRD 17924679
T239 Phosphorylation HPRD 17924679
T240 Phosphorylation HPRD 19413330, 17924679


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044815 (hFBXO4/iso:1/Phos:1) pS12 PRO 18598945, 21242966


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P02511 (CRYAB) S45 Q9UKT5 (FBXO4) unknown eFIP 12468532
Phosphorylation P02511 (CRYAB) S19 Q9UKT5 (FBXO4) unknown eFIP 12468532


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000044815 (hFBXO4/iso:1/Phos:1) Interaction PR:P62260 (rYWHAE) PRO 21242966
PR:000044815 (hFBXO4/iso:1/Phos:1) Interaction PR:P62260 (rYWHAE) PRO 21242966
PR:000044815 (hFBXO4/iso:1/Phos:1) Interaction PR:P62260 (rYWHAE) PRO 21242966


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 R8 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T10 K10 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R144 I144 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T239 A239 Biomuta DOID:363 / uterine cancer [ tcga ]