Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9P2R7 / SUCB1_HUMAN
Protein Name Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial precursor
Gene Name Name: SUCLA2
Organism Homo sapiens (Human)

DAG View
PRO Name succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (human)
Definition A succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial that is encoded in the genome of human.
Short Label hSUCLA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9P2R7 (SUCLA2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
Y75 Phosphorylation PhosphoSitePlus
K78 Acetylation PhosphoSitePlus   UniProt 19608861
K78 Ubiquitination PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus   RLIMS-P 33991485
Y84 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455
K88 Acetylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K89 Acetylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
R106 Methylation PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K116 Acetylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K143 Acetylation PhosphoSitePlus   UniProt 19608861
K143 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
K302 Acetylation PhosphoSitePlus
T341 Phosphorylation PhosphoSitePlus
K368 Acetylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
T448 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 20068231
Y84 Phosphorylation HPRD 15592455
S444 Phosphorylation HPRD 20068231
T448 Phosphorylation HPRD 20068231

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9P2R7 (SUCLA2) S79 O94925 (GLS) unknown eFIP 33991485

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R106 T106 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K120 N120 Biomuta DOID:1324 / lung cancer [ cosmic ]
S132 C132 Biomuta DOID:1612 / breast cancer [ icgc ]
S279 F279 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]