iPTMnet Report for Q9P2P5 (HECW2)
Protein Information
UniProt AC / UniProt ID | Q9P2P5 / HECW2_HUMAN |
Protein Name | E3 ubiquitin-protein ligase HECW2 |
Gene Name | Name: HECW2 Synonyms:KIAA1301,NEDL2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9P2P5 |
PRO Name | E3 ubiquitin-protein ligase HECW2 (human) |
Definition | An E3 ubiquitin-protein ligase HECW2 that is encoded in the genome of human. |
Short Label | hHECW2 |
Category | organism-gene |
Q9P2P5 (HECW2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S3 | Phosphorylation | score1 | PhosphoSitePlus | |||
S4 | Phosphorylation | score1 | PhosphoSitePlus | |||
S24 | Phosphorylation | score1 | PhosphoSitePlus | |||
S48 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163 | ||
T50 | Phosphorylation | score1 | PhosphoSitePlus | |||
C156 | Methylation | score1 | IEDB | 31844290 | ||
K183 | Ubiquitination | score1 | PhosphoSitePlus | |||
K198 | Ubiquitination | score1 | PhosphoSitePlus | |||
K199 | Methylation | score1 | PhosphoSitePlus | |||
Y208 | Phosphorylation | score1 | PhosphoSitePlus | |||
K210 | Ubiquitination | score1 | PhosphoSitePlus | |||
K218 | Ubiquitination | score1 | PhosphoSitePlus | |||
S220 | Phosphorylation | score1 | PhosphoSitePlus | |||
S390 | Phosphorylation | score1 | PhosphoSitePlus | |||
T396 | Phosphorylation | score1 | PhosphoSitePlus | |||
S444 | Phosphorylation | score1 | PhosphoSitePlus | |||
T453 | Phosphorylation | score1 | PhosphoSitePlus | |||
S465 | Phosphorylation | score1 | PhosphoSitePlus | |||
C660 | Methylation | score1 | IEDB | 31844290 | ||
S742 | Phosphorylation | score1 | PhosphoSitePlus | |||
S850 | Phosphorylation | score1 | PhosphoSitePlus | |||
S852 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S865 | Phosphorylation | score1 | PhosphoSitePlus | |||
S909 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S1027 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1040 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1042 | Phosphorylation | score1 | PhosphoSitePlus | |||
T1064 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1171 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1175 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
S1237 | Phosphorylation | score1 | PhosphoSitePlus | |||
T1398 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1439 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S3 | N3 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
S4 | L4 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S24 | C24 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
S24 | I24 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
K210 | N210 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S390 | F390 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S465 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
C660 | * | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
S742 | N742 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S852 | F852 | Biomuta | [ cosmic ] | |
S909 | F909 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
S1040 | R1040 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
S1171 | F1171 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S1439 | C1439 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
S1439 | T1439 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |