Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NZJ0 / DTL_HUMAN
Protein Name Denticleless protein homolog
Gene Name Name: DTL
Synonyms:CDT2,CDW1,DCAF2,L2DTL,RAMP;
Organism Homo sapiens (Human)

PRO ID PR:Q9NZJ0
DAG View
PRO Name denticleless protein homolog (human)
Definition A denticleless protein that is encoded in the genome of human.
Short Label hDTL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NZJ0 (DTL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
K123 Ubiquitination PhosphoSitePlus
K128 Sumoylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K137 Sumoylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
K175 Sumoylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus   UniProt 23186163
S198 Phosphorylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
Y249 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
K397 Sumoylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K402 Sumoylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K412 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
T422 Phosphorylation PhosphoSitePlus
T424 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
S426 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
S428 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T429 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K432 Sumoylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
T464 Phosphorylation P06493 (CDK1) PhosphoSitePlus   RLIMS-P   UniProt 23478441
T471 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
S485 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S487 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
S490 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S495 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S496 Phosphorylation PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
T508 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S510 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S511 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S512 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935, 18669648, ...19690332, 20068231
T516 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332, 20068231
S520 Phosphorylation PhosphoSitePlus
K523 Sumoylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
K529 Sumoylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
S557 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S558 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
S619 Phosphorylation PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
S626 Phosphorylation PhosphoSitePlus
S656 Phosphorylation PhosphoSitePlus
K660 Sumoylation PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
S676 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S679 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S681 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S682 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T684 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S687 Phosphorylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
S697 Phosphorylation PhosphoSitePlus
T700 Phosphorylation PhosphoSitePlus
T702 Phosphorylation PhosphoSitePlus   UniProt 23186163
K708 Sumoylation PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
S717 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K199 E199 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S425 N425 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S444 F444 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S446 L446 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S488 F488 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S510 P510 Biomuta DOID:3277 / thymus cancer [ tcga ]
T516 P516 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S520 L520 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
K552 R552 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S679 T679 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S679 N679 Biomuta DOID:5041 / esophageal cancer [ tcga ]