Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NRI5 / DISC1_HUMAN
Protein Name Disrupted in schizophrenia 1 protein
Gene Name Name: DISC1
Synonyms:KIAA0457;
Organism Homo sapiens (Human)

PRO ID PR:Q9NRI5
DAG View
PRO Name disrupted in schizophrenia 1 protein (human)
Definition A disrupted in schizophrenia 1 protein that is encoded in the genome of human.
Short Label hDISC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NRI5 (DISC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R21 Methylation PhosphoSitePlus
T50 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
T107 Phosphorylation PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
R112 Methylation PhosphoSitePlus
T198 Phosphorylation RLIMS-P 28727686
S202 Phosphorylation RLIMS-P 28727686
S241 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus   UniProt 28727686
K387 Ubiquitination PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K563 Ubiquitination PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
S626 Phosphorylation PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K643 Sumoylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
K670 Methylation PhosphoSitePlus
K678 Methylation PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus   RLIMS-P 29324815
K753 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S556 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P49841 (GSK3B) S9 Q9NRI5 (DISC1) unknown eFIP 30285728
Phosphorylation Q9NRI5 (DISC1) T198 Q969H0 (FBXW7) unknown eFIP 28727686