Protein Information

Cytoscape View

UniProt AC / UniProt ID Q99801 / NKX31_HUMAN
Protein Name Homeobox protein Nkx-3.1
Gene Name Name: NKX3-1
Organism Homo sapiens (Human)

PRO ID PR:Q99801
DAG View
PRO Name homeobox protein Nkx-3.1 (human)
Definition A homeobox protein Nkx-3.1 that is encoded in the genome of human.
Short Label hNKX3-1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q99801 (NKX3-1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T21 Phosphorylation PhosphoSitePlus
S48 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   RLIMS-P   Signor 11980664
T89 Phosphorylation P11309 (PIM1) , P19784 (CSNK2A2) PhosphoSitePlus   RLIMS-P   Signor 16581776, 23129228
T93 Phosphorylation P19784 (CSNK2A2) PhosphoSitePlus   RLIMS-P   Signor 16581776
T134 Phosphorylation Q13315 (ATM) PhosphoSitePlus 23890999
K159 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
T166 Phosphorylation Q13315 (ATM) PhosphoSitePlus 23890999
K182 Ubiquitination PhosphoSitePlus
S185 Phosphorylation P11309 (PIM1) , Q9Y463 (DYRK1B) PhosphoSitePlus   RLIMS-P+   RLIMS-P 25777618, 23129228
S186 Phosphorylation P11309 (PIM1) PhosphoSitePlus   RLIMS-P 23129228
S195 Phosphorylation P11309 (PIM1) PhosphoSitePlus 23129228
S196 Phosphorylation P11309 (PIM1) PhosphoSitePlus   RLIMS-P 18757402, 23129228
Y222 Phosphorylation PhosphoSitePlus   RLIMS-P 23890999

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T134 I134 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K182 M182 Biomuta DOID:363 / uterine cancer [ tcga ]
S196 F196 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]