Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99798 / ACON_HUMAN
Protein Name Aconitate hydratase, mitochondrial precursor
Gene Name Name: ACO2
Organism Homo sapiens (Human)

PRO ID PR:Q99798
DAG View
PRO Name aconitate hydratase, mitochondrial (human)
Definition An aconitate hydratase, mitochondrial that is encoded in the genome of human.
Short Label hACO2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99798 (ACO2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation PhosphoSitePlus
Y42 Phosphorylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus
Y71 Phosphorylation P09769 (FGR) neXtProt 17997986
S79 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
K144 Acetylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
Y151 Phosphorylation PhosphoSitePlus
S193 O-Glycosylation GlyGen 32119511, 28510447, 29351928
K233 Acetylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus
K370 Acetylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
Y390 Phosphorylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
C410 S-Nitrosylation dbSNO 24105792
K411 Ubiquitination PhosphoSitePlus
Y432 Phosphorylation PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
T470 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
R474 Methylation PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
Y513 Phosphorylation PhosphoSitePlus
T515 Phosphorylation PhosphoSitePlus
K520 Acetylation PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
K521 Acetylation PhosphoSitePlus
R523 Methylation PhosphoSitePlus
K534 Acetylation PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
T543 Phosphorylation PhosphoSitePlus
Y544 Phosphorylation P09769 (FGR) neXtProt   PhosphoSitePlus 17997986
K549 Acetylation PhosphoSitePlus
S559 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 20068231
K573 Acetylation PhosphoSitePlus   UniProt 19608861
K573 Ubiquitination PhosphoSitePlus
K577 Acetylation PhosphoSitePlus
C592 S-Nitrosylation dbSNO 19483679, 22178444
K605 Acetylation PhosphoSitePlus   UniProt 19608861
K605 Ubiquitination PhosphoSitePlus
T646 Phosphorylation PhosphoSitePlus
Y665 Phosphorylation P09769 (FGR) neXtProt   PhosphoSitePlus 17997986
S669 Phosphorylation PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
R679 Methylation PhosphoSitePlus
K689 Acetylation PhosphoSitePlus
K689 Ubiquitination PhosphoSitePlus
K700 Acetylation PhosphoSitePlus
K701 Ubiquitination PhosphoSitePlus
K723 Ubiquitination PhosphoSitePlus
K730 Acetylation PhosphoSitePlus
K730 Ubiquitination PhosphoSitePlus
K743 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S87 L87 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K233 N233 Biomuta DOID:3571 / liver cancer [ icgc ]
S471 F471 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T515 M515 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T515 A515 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K577 E577 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y665 H665 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R679 C679 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]