Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96JB3 / HIC2_HUMAN
Protein Name Hypermethylated in cancer 2 protein
Gene Name Name: HIC2
Synonyms:HRG22,KIAA1020,ZBTB30;
Organism Homo sapiens (Human)

PRO ID PR:Q96JB3
DAG View
PRO Name hypermethylated in cancer 2 protein (human)
Definition A hypermethylated in cancer 2 protein that is encoded in the genome of human.
Short Label hHIC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96JB3 (HIC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S153 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus   UniProt 23186163
S169 Phosphorylation PhosphoSitePlus   UniProt 23186163
S197 Phosphorylation PhosphoSitePlus   UniProt 23186163
S253 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus   UniProt 23186163
S409 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus   UniProt 23186163
T612 Phosphorylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S197 Phosphorylation HPRD 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S197 L197 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T612 A612 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S613 P613 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S613 Y613 Biomuta DOID:1909 / melanoma [ tcga ]