Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TCS8 / PNPT1_HUMAN
Protein Name Polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor
Gene Name Name: PNPT1
Synonyms:PNPASE;
Organism Homo sapiens (Human)

PRO ID PR:Q8TCS8
DAG View
PRO Name polyribonucleotide nucleotidyltransferase 1, mitochondrial (human)
Definition A polyribonucleotide nucleotidyltransferase 1, mitochondrial that is encoded in the genome of human.
Short Label hPNPT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TCS8 (PNPT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K55 Acetylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
S91 Phosphorylation HPRD 20068231
Y102 Phosphorylation HPRD 20068231
K126 Acetylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
K250 Acetylation PhosphoSitePlus
K264 Acetylation PhosphoSitePlus   UniProt 19608861
T272 Phosphorylation HPRD   PhosphoSitePlus 20068230
K275 Acetylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
K285 Acetylation PhosphoSitePlus   UniProt 19608861
K285 Ubiquitination PhosphoSitePlus
K289 Acetylation PhosphoSitePlus   UniProt 19608861
Y296 Phosphorylation PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
K306 Acetylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K327 Acetylation PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
Y334 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
S350 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y356 Phosphorylation HPRD   PhosphoSitePlus 20068231
K357 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
K439 Acetylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
Y459 Phosphorylation PhosphoSitePlus
T473 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
K521 Acetylation PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
K569 Methylation PhosphoSitePlus
K591 Acetylation PhosphoSitePlus
K591 Ubiquitination PhosphoSitePlus
T592 Phosphorylation PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
Y626 Phosphorylation PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
T665 Phosphorylation PhosphoSitePlus
T683 Phosphorylation PhosphoSitePlus
T687 Phosphorylation PhosphoSitePlus
T721 Phosphorylation PhosphoSitePlus
S754 Phosphorylation PhosphoSitePlus   UniProt 23186163
T758 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
S776 Phosphorylation P78527 (PRKDC) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 17525332, 22815474
S782 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 21406692


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S59 T59 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S280 L280 Biomuta DOID:1612 / breast cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y334 S334 Biomuta DOID:11934 / head and neck cancer [ tcga ]
Y334 C334 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S474 F474 Biomuta DOID:363 / uterine cancer [ tcga ]
K521 N521 Biomuta DOID:1324 / lung cancer [ cosmic ]
S782 Y782 Biomuta DOID:1115 / sarcoma [ tcga ]