Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NC56 / LEMD2_HUMAN
Protein Name LEM domain-containing protein 2
Gene Name Name: LEMD2
Organism Homo sapiens (Human)

PRO ID PR:Q8NC56
DAG View
PRO Name LEM domain-containing protein 2 (human)
Definition A LEM domain-containing protein 2 that is encoded in the genome of human.
Short Label hLEMD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NC56 (LEMD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S5 Phosphorylation PhosphoSitePlus
R10 Methylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
Y98 Phosphorylation PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
R108 Methylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
R118 Methylation PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus
S134 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S138 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S139 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
T147 Phosphorylation PhosphoSitePlus
T152 Phosphorylation PhosphoSitePlus
R160 Methylation PhosphoSitePlus
S166 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S174 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus   UniProt 23186163
K264 Methylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K266 Methylation PhosphoSitePlus
N311 N-Glycosylation GlyGen 24190977
K319 Acetylation PhosphoSitePlus
Y436 Phosphorylation PhosphoSitePlus
Y438 Phosphorylation PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus   UniProt 21406692
S499 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
S501 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S82 Phosphorylation HPRD 20068231, 17924679
S134 Phosphorylation HPRD 18669648
S138 Phosphorylation HPRD 19651622, 18669648
S139 Phosphorylation HPRD 19651622, 18669648
T147 Phosphorylation HPRD 19651622
S166 Phosphorylation HPRD 18669648
S499 Phosphorylation HPRD 18452278, 19651622, 18669648, ...20166139, 19415658, 20068231
S501 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 G2 Biomuta DOID:1612 / breast cancer [ cosmic ]
R10 P10 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S82 F82 Biomuta DOID:1612 / breast cancer [ icgc ]
R108 L108 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y436 C436 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc, tcga ]
S499 C499 Biomuta DOID:1612 / breast cancer [ icgc ]