Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N4C8 / MINK1_HUMAN
Protein Name Misshapen-like kinase 1
Gene Name Name: MINK1
Synonyms:B55,MAP4K6;
Organism Homo sapiens (Human)

PRO ID PR:Q8N4C8
DAG View
PRO Name misshapen-like kinase 1 (human)
Definition A misshapen-like kinase 1 that is encoded in the genome of human.
Short Label hMINK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N4C8 (MINK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
Y36 Phosphorylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
Y86 Phosphorylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
T187 Phosphorylation Q8N4C8 (MINK1) neXtProt   phospho.ELM   PhosphoSitePlus 12507505, 15302935
T191 Phosphorylation Q8N4C8 (MINK1) neXtProt   phospho.ELM   PhosphoSitePlus 12507505, 15302935
Y193 Phosphorylation Q8N4C8 (MINK1) neXtProt   phospho.ELM   PhosphoSitePlus 12507505, 15302935
T280 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
K303 Ubiquitination PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
Y323 Phosphorylation PhosphoSitePlus
S324 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S326 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S332 Phosphorylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
Y475 Phosphorylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
Y505 Phosphorylation PhosphoSitePlus
Y507 Phosphorylation PhosphoSitePlus
R509 Methylation PhosphoSitePlus   UniProt 24129315
S535 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
T565 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
K590 Acetylation PhosphoSitePlus
K590 Methylation PhosphoSitePlus
Y592 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
T629 Phosphorylation PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163
T644 Phosphorylation PhosphoSitePlus
T672 O-Glycosylation GlyGen 28657654
S673 Phosphorylation PhosphoSitePlus
S674 Phosphorylation PhosphoSitePlus
S699 Phosphorylation PhosphoSitePlus
S701 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y706 Phosphorylation PhosphoSitePlus
S732 Phosphorylation PhosphoSitePlus
S733 Phosphorylation PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus
S749 Phosphorylation PhosphoSitePlus
S754 Phosphorylation PhosphoSitePlus   UniProt 23186163
S763 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 18088087, ...17081983, 18220336, 18691976, 18669648, 24275569, 23186163, 20068231
S772 Phosphorylation PhosphoSitePlus
S773 Phosphorylation PhosphoSitePlus
S777 Phosphorylation PhosphoSitePlus   UniProt 18669648
S778 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 18669648, 23186163, ...19690332
S782 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648
T809 Phosphorylation PhosphoSitePlus
S903 Phosphorylation PhosphoSitePlus
Y906 Phosphorylation PhosphoSitePlus
T907 Phosphorylation PhosphoSitePlus
S916 Phosphorylation PhosphoSitePlus
S918 Phosphorylation PhosphoSitePlus
T920 Phosphorylation PhosphoSitePlus
S927 Phosphorylation PhosphoSitePlus
K931 Ubiquitination PhosphoSitePlus
Y937 Phosphorylation PhosphoSitePlus
S939 Phosphorylation PhosphoSitePlus
Y960 Phosphorylation PhosphoSitePlus
Y987 Phosphorylation PhosphoSitePlus
S993 Phosphorylation PhosphoSitePlus
T1008 Phosphorylation PhosphoSitePlus
S1088 Phosphorylation PhosphoSitePlus
K1103 Ubiquitination PhosphoSitePlus
K1146 Ubiquitination PhosphoSitePlus
K1150 Ubiquitination PhosphoSitePlus
K1291 Ubiquitination PhosphoSitePlus
K1297 Ubiquitination PhosphoSitePlus
K1305 Ubiquitination PhosphoSitePlus
S1317 Phosphorylation PhosphoSitePlus
Y1320 Phosphorylation PhosphoSitePlus
T1323 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 20068231
T35 Phosphorylation HPRD 18452278
Y40 Phosphorylation HPRD 18452278
S175 Phosphorylation HPRD 18691976
T187 Phosphorylation HPRD 18691976
T319 Phosphorylation HPRD 18691976
Y321 Phosphorylation HPRD 18691976
Y323 Phosphorylation HPRD 18691976
S324 Phosphorylation HPRD 18691976, 18452278
S326 Phosphorylation HPRD 18691976, 18452278
S332 Phosphorylation HPRD 18691976, 18452278
S340 Phosphorylation HPRD 18691976
S535 Phosphorylation HPRD 18691976
S601 Phosphorylation HPRD 18691976
S641 Phosphorylation HPRD 18691976
T644 Phosphorylation HPRD 18691976
S701 Phosphorylation HPRD 18669648
S763 Phosphorylation HPRD 18691976, 18088087, 17081983, ...19651622, 18669648, 20068231
S772 Phosphorylation HPRD 20068231
S777 Phosphorylation HPRD 18691976, 18669648
S778 Phosphorylation HPRD 19651622, 18669648, 18491316, ...15302935
S782 Phosphorylation HPRD 18691976, 18669648
Y906 Phosphorylation HPRD 17016520, 17389395
S916 Phosphorylation HPRD 18691976, 20068231, 18452278
S918 Phosphorylation HPRD 18452278
S1006 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 20068231
T35 Phosphorylation HPRD 18452278
Y40 Phosphorylation HPRD 18452278
S175 Phosphorylation HPRD 18691976
T187 Phosphorylation HPRD 18691976
T319 Phosphorylation HPRD 18691976
Y321 Phosphorylation HPRD 18691976
Y323 Phosphorylation HPRD 18691976
S324 Phosphorylation HPRD 18691976, 18452278
S326 Phosphorylation HPRD 18691976, 18452278
S332 Phosphorylation HPRD 18691976, 18452278
S340 Phosphorylation HPRD 18691976
S535 Phosphorylation HPRD 18691976
S601 Phosphorylation HPRD 18691976
S641 Phosphorylation HPRD 18691976
T644 Phosphorylation HPRD 18691976
S696 Phosphorylation PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
S726 Phosphorylation HPRD 18691976, 18088087, 17081983, ...19651622, 18669648, 20068231
S735 Phosphorylation HPRD 20068231
S740 Phosphorylation HPRD 18691976, 18669648
S741 Phosphorylation HPRD 19651622, 18669648, 18491316, ...15302935
S745 Phosphorylation HPRD 18691976, 18669648
Y869 Phosphorylation HPRD 17016520, 17389395
S879 Phosphorylation HPRD 18691976, 20068231, 18452278
S881 Phosphorylation HPRD 18452278
S969 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 20068231
T35 Phosphorylation HPRD 18452278
Y40 Phosphorylation HPRD 18452278
S175 Phosphorylation HPRD 18691976
T187 Phosphorylation HPRD 18691976
T319 Phosphorylation HPRD 18691976
Y321 Phosphorylation HPRD 18691976
Y323 Phosphorylation HPRD 18691976
S324 Phosphorylation HPRD 18691976, 18452278
S326 Phosphorylation HPRD 18691976, 18452278
S332 Phosphorylation HPRD 18691976, 18452278
S340 Phosphorylation HPRD 18691976
S535 Phosphorylation HPRD 18691976
S601 Phosphorylation HPRD 18691976
S641 Phosphorylation HPRD 18691976
T644 Phosphorylation HPRD 18691976
S696 Phosphorylation PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
S726 Phosphorylation HPRD 18691976, 18088087, 17081983, ...19651622, 18669648, 20068231
S735 Phosphorylation HPRD 20068231
S740 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648
S741 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 18491316, ...15302935
S745 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648
K751 Ubiquitination PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
S764 Phosphorylation PhosphoSitePlus
K766 Ubiquitination PhosphoSitePlus
Y877 Phosphorylation HPRD   PhosphoSitePlus 17016520, 17389395
S887 Phosphorylation HPRD 18691976, 20068231, 18452278
S889 Phosphorylation HPRD 18452278
S977 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 20068231
T35 Phosphorylation HPRD 18452278
Y40 Phosphorylation HPRD 18452278
S175 Phosphorylation HPRD 18691976
T187 Phosphorylation HPRD 18691976
T319 Phosphorylation HPRD 18691976
Y321 Phosphorylation HPRD 18691976
Y323 Phosphorylation HPRD 18691976
S324 Phosphorylation HPRD 18691976, 18452278
S326 Phosphorylation HPRD 18691976, 18452278
S332 Phosphorylation HPRD 18691976, 18452278
S340 Phosphorylation HPRD 18691976
S535 Phosphorylation HPRD 18691976
S621 Phosphorylation HPRD 18691976
T624 Phosphorylation HPRD 18691976
S681 Phosphorylation HPRD 18669648
S743 Phosphorylation HPRD 18691976, 18088087, 17081983, ...19651622, 18669648, 20068231
S752 Phosphorylation HPRD 20068231
S757 Phosphorylation HPRD 18691976, 18669648
S758 Phosphorylation HPRD 19651622, 18669648, 18491316
S762 Phosphorylation HPRD 18691976, 18669648
Y886 Phosphorylation HPRD 17016520, 17389395
S896 Phosphorylation HPRD 18691976, 20068231, 18452278
S898 Phosphorylation HPRD 18452278
S986 Phosphorylation HPRD 18691976


Q8N4C8 (MINK1) as PTM Enzyme



Substrate Site Score Source PMID
Q15797 (SMAD1) T322 neXtProt 21690388
Q8N4C8 (MINK1) T187 neXtProt 12507505
Q8N4C8 (MINK1) T191 neXtProt 12507505
Q8N4C8 (MINK1) Y193 neXtProt 12507505
Q96MT3 (PRICKLE1) T370 neXtProt 22037766


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T280 M280 Biomuta DOID:363 / uterine cancer [ tcga ]
T319 I319 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S326 I326 Biomuta DOID:1115 / sarcoma [ tcga ]
R509 Q509 Biomuta DOID:1909 / melanoma [ icgc ]
T629 M629 Biomuta DOID:2531 / hematologic cancer [ icgc ]
T672 A672 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S740 R740 Biomuta DOID:363 / uterine cancer [ icgc ]
S754 C754 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S778 F778 Biomuta DOID:363 / uterine cancer [ tcga ]
K931 N931 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
Y1320 S1320 Biomuta DOID:263 / kidney cancer [ tcga ]