Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IZF0 / NALCN_HUMAN
Protein Name Sodium leak channel non-selective protein
Gene Name Name: NALCN
Synonyms:VGCNL1;
Organism Homo sapiens (Human)

PRO ID PR:Q8IZF0
DAG View
PRO Name sodium leak channel non-selective protein (human)
Definition A sodium leak channel non-selective protein that is encoded in the genome of human.
Short Label hNALCN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IZF0 (NALCN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T165 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
Y497 Phosphorylation PhosphoSitePlus
T623 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
T917 Phosphorylation PhosphoSitePlus
Y923 Phosphorylation PhosphoSitePlus
S1066 Phosphorylation PhosphoSitePlus
S1068 Phosphorylation PhosphoSitePlus
K1069 Acetylation PhosphoSitePlus
Y1298 Phosphorylation PhosphoSitePlus
Y1362 Phosphorylation PhosphoSitePlus
S1682 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y497 Phosphorylation HPRD 15592455


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S489 * Biomuta DOID:363 / uterine cancer [ tcga ]
T623 I623 Biomuta DOID:363 / uterine cancer [ tcga ]
S742 L742 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T917 N917 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y923 C923 Biomuta DOID:1324 / lung cancer [ tcga ]
S1066 I1066 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1068 A1068 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1069 N1069 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc ] DOID:11934 / head and neck cancer [ tcga ]