Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86YW9 / MD12L_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 12-like protein
Gene Name Name: MED12L
Synonyms:KIAA1635,TNRC11L,TRALP,TRALPUSH;ORFNames:PRO0314;
Organism Homo sapiens (Human)

PRO ID PR:Q86YW9
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 12-like protein (human)
Definition A mediator of RNA polymerase II transcription subunit 12-like protein that is encoded in the genome of human.
Short Label hMED12L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86YW9 (MED12L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K82 Ubiquitination PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
T462 Phosphorylation PhosphoSitePlus   UniProt 18669648
T474 Phosphorylation PhosphoSitePlus
Y484 Phosphorylation PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
T630 Phosphorylation PhosphoSitePlus
S632 Phosphorylation PhosphoSitePlus
T633 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
T671 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
K735 Ubiquitination PhosphoSitePlus
K746 Ubiquitination PhosphoSitePlus
K749 Ubiquitination PhosphoSitePlus
K771 Ubiquitination PhosphoSitePlus
S922 Phosphorylation PhosphoSitePlus
S923 Phosphorylation PhosphoSitePlus
K956 Ubiquitination PhosphoSitePlus
K958 Ubiquitination PhosphoSitePlus
K998 Ubiquitination PhosphoSitePlus
K1150 Ubiquitination PhosphoSitePlus
K1200 Ubiquitination PhosphoSitePlus
T1220 Phosphorylation PhosphoSitePlus
S1222 Phosphorylation PhosphoSitePlus
K1226 Ubiquitination PhosphoSitePlus
K1230 Ubiquitination PhosphoSitePlus
K1298 Ubiquitination PhosphoSitePlus
K1339 Ubiquitination PhosphoSitePlus
K1431 Ubiquitination PhosphoSitePlus
K1457 Ubiquitination PhosphoSitePlus
T1487 Phosphorylation PhosphoSitePlus
K1510 Ubiquitination PhosphoSitePlus
S1615 Phosphorylation PhosphoSitePlus
K1650 Ubiquitination PhosphoSitePlus
K1660 Ubiquitination PhosphoSitePlus
K1668 Ubiquitination PhosphoSitePlus
K1670 Ubiquitination PhosphoSitePlus
S1755 Phosphorylation PhosphoSitePlus
K1851 Ubiquitination PhosphoSitePlus
T2116 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T462 Phosphorylation HPRD 18669648
T474 Phosphorylation HPRD 18669648
Y484 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S137 I137 Biomuta DOID:1612 / breast cancer [ cosmic ]
T462 M462 Biomuta DOID:1909 / melanoma [ cosmic ] DOID:1324 / lung cancer [ tcga ]
S632 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K956 N956 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K1150 N1150 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K1200 N1200 Biomuta DOID:363 / uterine cancer [ tcga ]
K1660 N1660 Biomuta DOID:1324 / lung cancer [ cosmic ]
T2116 M2116 Biomuta DOID:1793 / pancreatic cancer [ icgc ]