Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z434 / MAVS_HUMAN
Protein Name Mitochondrial antiviral-signaling protein
Gene Name Name: MAVS
Synonyms:IPS1,KIAA1271,VISA;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z434
DAG View
PRO Name mitochondrial antiviral-signaling protein (human)
Definition A mitochondrial antiviral-signaling protein that is encoded in the genome of human.
Short Label hMAVS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z434 (MAVS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Ubiquitination PhosphoSitePlus
Y9 Phosphorylation PhosphoSitePlus   RLIMS-P 22844514
K10 Ubiquitination PhosphoSitePlus
Y11 Phosphorylation PhosphoSitePlus
Y30 Phosphorylation PhosphoSitePlus
T45 Phosphorylation PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
T121 Phosphorylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
S152 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 24275569
S157 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T163 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S165 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 24275569
S180 Phosphorylation PhosphoSitePlus   UniProt 24275569
S188 Phosphorylation PhosphoSitePlus   UniProt 24275569
T215 Phosphorylation PhosphoSitePlus   UniProt 24275569
S222 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18220336, ...18669648, 24275569, 18088087
S224 Phosphorylation PhosphoSitePlus
R232 Methylation PhosphoSitePlus
S233 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T234 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
R239 Methylation PhosphoSitePlus
T244 Phosphorylation phospho.ELM 18669648
S246 Phosphorylation phospho.ELM 18669648
S249 Phosphorylation phospho.ELM 18669648
T250 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T252 Phosphorylation phospho.ELM 18669648
S253 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S255 Phosphorylation phospho.ELM 18669648
S256 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S257 Phosphorylation PhosphoSitePlus
S258 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S275 Phosphorylation PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
T301 O-Glycosylation GlyGen 23301498, 30543776, 30059200, ...29351928, 32119511, 28510447, 28657654, 29237092
T301 Phosphorylation PhosphoSitePlus
T307 O-Glycosylation GlyGen 23301498, 30543776, 30059200, ...29351928, 32119511, 28510447, 28657654, 29237092
T307 Phosphorylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
S324 O-Glycosylation PhosphoSitePlus
T328 O-Glycosylation PhosphoSitePlus
S329 O-Glycosylation PhosphoSitePlus
S330 O-Glycosylation PhosphoSitePlus
S338 O-Glycosylation PhosphoSitePlus
T342 O-Glycosylation PhosphoSitePlus
S347 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 30543776, 30059200, ...29351928, 32119511, 28510447, 28657654, 29237092
S361 Phosphorylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
T365 O-Glycosylation GlyGen 23301498, 30543776, 30059200, ...29351928, 32119511, 28510447, 28657654, 29237092
T365 Phosphorylation PhosphoSitePlus
S366 O-Glycosylation GlyGen 23301498, 30543776, 30059200, ...29351928, 32119511, 28510447, 28657654, 29237092
S366 Phosphorylation PhosphoSitePlus
T370 O-Glycosylation GlyGen 23301498, 30543776, 30059200, ...29351928, 32119511, 28510447, 28657654, 29237092
K371 Ubiquitination PRO
S373 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
K420 Ubiquitination PRO
S430 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 33205822, 25636800, 27302953
K461 Ubiquitination PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S152 Phosphorylation HPRD 18691976, 18669648, 20068231
S157 Phosphorylation HPRD 18669648
T163 Phosphorylation HPRD 18669648
S165 Phosphorylation HPRD 18691976, 18669648, 20068231
S222 Phosphorylation HPRD 19413330, 18691976, 18578522, ...16964243, 18767875, 20058876, 19664994, 18669648, 20166139, 19415658, 20068231
S233 Phosphorylation HPRD 18669648
T234 Phosphorylation HPRD 18669648
T244 Phosphorylation HPRD 18691976, 18669648, 20068231
S246 Phosphorylation HPRD 18691976, 18669648
S249 Phosphorylation HPRD 18691976, 18669648
T250 Phosphorylation HPRD 18669648, 20068231
T252 Phosphorylation HPRD 18691976, 18669648
S253 Phosphorylation HPRD 18669648, 20068231
S255 Phosphorylation HPRD 18669648
S256 Phosphorylation HPRD 18669648
S258 Phosphorylation HPRD 18691976, 18669648, 20068231
T398 Phosphorylation HPRD 18691976
S407 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048346 (hMAVS/Ubiq:1) ubK371,ubK420 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O95786 (DDX58) S8 Q7Z434 (MAVS) unknown eFIP 20406818
Phosphorylation O95786 (DDX58) T170 Q7Z434 (MAVS) unknown eFIP 20071582


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y9 C9 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R232 H232 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T234 P234 Biomuta DOID:11934 / head and neck cancer [ tcga ]
R239 H239 Biomuta DOID:363 / uterine cancer [ tcga ]
S256 P256 Biomuta DOID:1909 / melanoma [ tcga ]
S330 P330 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K362 E362 Biomuta DOID:363 / uterine cancer [ tcga ]
S416 * Biomuta DOID:1909 / melanoma [ tcga ]