Protein Information

Cytoscape View

UniProt AC / UniProt ID Q7LG56 / RIR2B_HUMAN
Protein Name Ribonucleoside-diphosphate reductase subunit M2 B
Gene Name Name: RRM2B
Organism Homo sapiens (Human)

DAG View
PRO Name ribonucleoside-diphosphate reductase subunit M2 B (human)
Definition A ribonucleoside-diphosphate reductase subunit M2 B that is encoded in the genome of human.
Short Label hRRM2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q7LG56 (RRM2B) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
R17 Methylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
S72 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 19015526
K166 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
K326 Acetylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
Y331 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S97 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R17 T17 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S20 L20 Biomuta DOID:1324 / lung cancer [ tcga ]
K166 N166 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]