Protein Information

Cytoscape View

UniProt AC / UniProt ID Q6PKX4 / DOK6_HUMAN
Protein Name Docking protein 6
Gene Name Name: DOK6
Organism Homo sapiens (Human)

DAG View
PRO Name docking protein 6 (human)
Definition A docking protein 6 that is encoded in the genome of human.
Short Label hDOK6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q6PKX4 (DOK6) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K58 Methylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P00533 (EGFR) Y998 Q6PKX4 (DOK6) unknown eFIP 16273093
Phosphorylation P04626 (ERBB2) Y1221 Q6PKX4 (DOK6) unknown eFIP 16273093

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S183 T183 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
S183 L183 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S262 P262 Biomuta DOID:363 / uterine cancer [ tcga ]
S262 Y262 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]