Protein Information

Cytoscape View

UniProt AC / UniProt ID Q5T1V6 / DDX59_HUMAN
Protein Name Probable ATP-dependent RNA helicase DDX59
Gene Name Name: DDX59
Organism Homo sapiens (Human)

DAG View
PRO Name probable ATP-dependent RNA helicase DDX59 (human)
Definition A probable ATP-dependent RNA helicase DDX59 that is encoded in the genome of human.
Short Label hDDX59
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q5T1V6 (DDX59) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
K26 Acetylation PhosphoSitePlus
K26 Sumoylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S64 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S76 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S156 Phosphorylation PhosphoSitePlus   UniProt 23186163
S160 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S165 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus
T227 Phosphorylation PhosphoSitePlus
S246 Phosphorylation phospho.ELM 18669648
K253 Ubiquitination PhosphoSitePlus
K270 Acetylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
Y317 Phosphorylation PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
K432 Acetylation PhosphoSitePlus
K440 Acetylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S64 Phosphorylation HPRD 18669648, 20068231
S76 Phosphorylation HPRD 18669648, 20068231
S160 Phosphorylation HPRD 18669648, 20068231, 18452278
S246 Phosphorylation HPRD 18669648

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S160 Y160 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K410 N410 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K432 E432 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K440 E440 Biomuta DOID:1324 / lung cancer [ tcga ]