Protein Information

Cytoscape View

UniProt AC / UniProt ID Q4G176 / ACSF3_HUMAN
Protein Name Malonate--CoA ligase ACSF3, mitochondrial precursor
Gene Name Name: ACSF3
Organism Homo sapiens (Human)

DAG View
PRO Name malonate--CoA ligase ACSF3, mitochondrial (human)
Definition A malonate--CoA ligase ACSF3, mitochondrial that is encoded in the genome of human.
Short Label hACSF3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q4G176 (ACSF3) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
R56 Methylation PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
T171 Phosphorylation PhosphoSitePlus
T205 Phosphorylation PhosphoSitePlus
T215 Phosphorylation HPRD 20068231
Y297 Phosphorylation PhosphoSitePlus
Y303 Phosphorylation PhosphoSitePlus
Y304 Phosphorylation PhosphoSitePlus
R306 Methylation PhosphoSitePlus
K324 Acetylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
Y355 Phosphorylation PhosphoSitePlus
C399 S-Nitrosylation dbSNO 26338901
K413 Ubiquitination PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K439 Acetylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
Y544 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T215 M215 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K324 N324 Biomuta DOID:1324 / lung cancer [ tcga ]
Y355 C355 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K462 N462 Biomuta DOID:3571 / liver cancer [ icgc ]