Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15910 / EZH2_HUMAN
Protein Name Histone-lysine N-methyltransferase EZH2
Gene Name Name: EZH2
Synonyms:KMT6;
Organism Homo sapiens (Human)

PRO ID PR:Q15910
DAG View
PRO Name histone-lysine N-methyltransferase EZH2 (human)
Definition A histone-lysine N-methyltransferase EZH2 that is encoded in the genome of human.
Short Label hEZH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15910 (EZH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Ubiquitination PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
S21 Phosphorylation P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 31189930, 29242551, 25431950, ...16224021, 24367927, 30575739, 21865393, 21659531, 24582688, 30736855
Y23 Phosphorylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
S73 O-Glycosylation GlyGen 29941599, 30093632
S75 O-Glycosylation GlyGen   UniProt 24474760
S76 O-Glycosylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus   UniProt 23186163
S84 O-Glycosylation GlyGen 29941599, 30093632
S87 O-Glycosylation GlyGen 29941599, 30093632
S212 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus   RLIMS-P 31434700
K234 Acetylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
Y244 Phosphorylation PhosphoSitePlus
T261 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
T302 Phosphorylation PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus   RLIMS-P 32884286
T313 O-Glycosylation GlyGen 29941599, 30093632
K318 Ubiquitination PhosphoSitePlus
T339 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T345 Phosphorylation P24941 (CDK2) , P06493 (CDK1) neXtProt   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 21123648, 25800736, 32895488, ...27716745, 21659531, 20935635, 32873321, 30282996
K348 Acetylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
S363 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P+   UniProt 23186163, 27494834
S366 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T367 Phosphorylation P49841 (GSK3B) , Q16539 (MAPK14) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 23186163, 30022044, 27494834, ...18669648, 20887952
T369 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
S380 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T388 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
T416 Phosphorylation P24941 (CDK2) PhosphoSitePlus   RLIMS-P   Signor 23241245, 26279746
T460 Phosphorylation PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
T487 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 25431950, 32537408, 25800736, ...27716745, 20935635, 32895488, 16964243, 18691976, 21406692, 23186163, 19690332, 30282996, 33593912, 18220336, 32873321, 17081983, 21123648, 32483123, 15302935, 27941792, 30575739, 18669648, 21659531, 20068231
K505 Methylation PhosphoSitePlus
K509 Methylation PhosphoSitePlus
K510 Methylation PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
Y641 Phosphorylation O60674 (JAK2) PhosphoSitePlus   RLIMS-P   Signor 32537408, 30159126, 26936398, ...24469040
S690 Phosphorylation PhosphoSitePlus
Y696 Phosphorylation PhosphoSitePlus
K713 Ubiquitination PhosphoSitePlus
T718 Phosphorylation PhosphoSitePlus
S729 O-Glycosylation GlyGen 29941599, 30093632
S729 Phosphorylation RLIMS-P 27468692
K735 Methylation PhosphoSitePlus
K735 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation P31749 (AKT1) HPRD 16224021
T344 Phosphorylation HPRD 18669648, 20068231
S371 Phosphorylation HPRD 18669648
T372 Phosphorylation HPRD 18669648, 19664994, 19691289, ...20068231
S385 Phosphorylation HPRD 17287340
S413 Phosphorylation HPRD 19413330
S417 Phosphorylation HPRD 19413330
T421 Phosphorylation HPRD 19413330, 20068231
T492 Phosphorylation HPRD 19413330, 18691976, 16964243, ...19664994, 19664995, 18452278, 17322306, 18669648, 19651622, 20068231
S652 Phosphorylation PhosphoSitePlus
S734 Phosphorylation Q13315 (ATM) HPRD   PhosphoSitePlus 24162653, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation P31749 (AKT1) HPRD 16224021
T300 Phosphorylation HPRD 18669648, 20068231
S327 Phosphorylation HPRD 18669648
T328 Phosphorylation HPRD 18669648, 19664994, 19691289, ...20068231
S341 Phosphorylation HPRD 17287340
S369 Phosphorylation HPRD 19413330
S373 Phosphorylation HPRD 19413330
T377 Phosphorylation HPRD 19413330, 20068231
T448 Phosphorylation HPRD 19413330, 18691976, 16964243, ...19664994, 19664995, 18452278, 17322306, 18669648, 19651622, 20068231
S690 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K39 E39 Biomuta DOID:1324 / lung cancer [ tcga ]
K61 R61 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]
S84 * Biomuta DOID:3571 / liver cancer [ icgc ]
S277 I277 Biomuta DOID:363 / uterine cancer [ tcga ]
K318 N318 Biomuta DOID:363 / uterine cancer [ tcga ]
S362 N362 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S375 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S405 L405 Biomuta DOID:1909 / melanoma [ tcga ]
T487 N487 Biomuta DOID:1612 / breast cancer [ tcga ]
K505 N505 Biomuta DOID:363 / uterine cancer [ tcga ]
K510 R510 Biomuta DOID:1612 / breast cancer [ tcga ] DOID:3277 / thymus cancer [ tcga ] DOID:1324 / lung cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ] DOID:2994 / germ cell cancer [ tcga ] DOID:1909 / melanoma [ tcga ] DOID:3571 / liver cancer [ tcga ] DOID:1115 / sarcoma [ tcga ] DOID:263 / kidney cancer [ tcga ] DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y641 N641 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y641 H641 Biomuta DOID:184 / bone cancer [ icgc ]
Y641 F641 Biomuta DOID:184 / bone cancer [ icgc ] DOID:1909 / melanoma [ tcga ]
Y641 S641 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y641 C641 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S690 L690 Biomuta DOID:4362 / cervical cancer [ icgc, tcga ]
T718 I718 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T718 N718 Biomuta DOID:3571 / liver cancer [ icgc ]
K735 N735 Biomuta DOID:9256 / colorectal cancer [ tcga ]