Protein Information

Cytoscape View

UniProt AC / UniProt ID Q14353 / GAMT_HUMAN
Protein Name Guanidinoacetate N-methyltransferase
Gene Name Name: GAMT
Organism Homo sapiens (Human)

PRO ID PR:Q14353
DAG View
PRO Name guanidinoacetate N-methyltransferase (human)
Definition A guanidinoacetate N-methyltransferase that is encoded in the genome of human.
Short Label hGAMT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q14353 (GAMT) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22223895
S17 Phosphorylation PhosphoSitePlus
Y27 Phosphorylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K109 N109 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
Y223 C223 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:3963 / thyroid carcinoma [ cosmic, icgc ]