Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12996 / CSTF3_HUMAN
Protein Name Cleavage stimulation factor subunit 3
Gene Name Name: CSTF3
Organism Homo sapiens (Human)

PRO ID PR:Q12996
DAG View
PRO Name cleavage stimulation factor subunit 3 (human)
Definition A cleavage stimulation factor subunit 3 that is encoded in the genome of human.
Short Label hCSTF3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12996 (CSTF3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22223895
S2 Phosphorylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
K114 Acetylation PhosphoSitePlus
Y126 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
Y140 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
T266 Phosphorylation PhosphoSitePlus
T273 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
K355 Acetylation PhosphoSitePlus
K358 Acetylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
Y534 Phosphorylation PhosphoSitePlus
K542 Acetylation PhosphoSitePlus
Y546 Phosphorylation PhosphoSitePlus
K547 Acetylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus
K682 Ubiquitination PhosphoSitePlus
S691 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 18220336, 18318008, 18669648, 24275569, 19690332, 20068231
Y708 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T266 Phosphorylation HPRD 20068231
T273 Phosphorylation HPRD 20068231
S691 Phosphorylation HPRD 19413330, 18691976, 17081983, ...20230923, 18452278, 19651622, 18669648, 18707149, 20166139, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q00403 (GTF2B) S65 Q12996 (CSTF3) unknown eFIP 20226668


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y104 F104 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S261 N261 Biomuta DOID:263 / kidney cancer [ tcga ]
T273 K273 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K529 R529 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S691 L691 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]