Protein Information

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UniProt AC / UniProt ID Q12888 / TP53B_HUMAN
Protein Name TP53-binding protein 1
Gene Name Name: TP53BP1
Organism Homo sapiens (Human)

PRO ID PR:Q12888
DAG View
PRO Name TP53-binding protein 1 (human)
Definition A TP53-binding protein 1 that is encoded in the genome of human.
Short Label hTP53BP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12888 (TP53BP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Sumoylation PRO
S6 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   Signor 12697768
S25 Phosphorylation Q13315 (ATM) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19876065, 17553757, 12697768, ...27494840, 29328365, 22421153, 20660628, 19176521, 19915695, 21680038
S29 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12697768, 17553757
K54 Acetylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus   UniProt 23186163
S78 Phosphorylation PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
S105 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
T117 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S127 Phosphorylation PhosphoSitePlus
K135 Methylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29328365, 17553757
S176 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29328365, 17553757
S178 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29328365, 17553757
Y188 Phosphorylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
K217 Acetylation PhosphoSitePlus
K217 Sumoylation PhosphoSitePlus
S222 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 23186163, ...17081983
S232 Phosphorylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K244 Acetylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
S265 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S280 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S294 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...17553757, 15302935, 18669648, 24275569, 19690332, 20068231
S301 Phosphorylation PhosphoSitePlus
T302 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 29328365, 17525332, 17553757, ...22621922
S310 Phosphorylation PhosphoSitePlus
T313 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
S316 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
S320 Phosphorylation PhosphoSitePlus
T321 Phosphorylation PhosphoSitePlus
S323 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T334 Phosphorylation PhosphoSitePlus
T337 Phosphorylation PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 31135337, 23186163, 19690332
T373 Phosphorylation PhosphoSitePlus
S379 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S380 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 27477698, 15302935, 23186163, ...17081983, 18220336, 17553757, 25607646, 18669648, 22067460, 20126263, 19690332
T382 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T394 Phosphorylation PhosphoSitePlus
S395 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 25607646
S398 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S452 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29328365, 17553757
S482 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
S493 Phosphorylation phospho.ELM 18669648
S500 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 24275569, 19690332, 20068231
S507 Phosphorylation PhosphoSitePlus   UniProt 23186163
T509 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
C513 S-Nitrosylation dbSNO 26338901
S518 Phosphorylation PhosphoSitePlus   UniProt 23186163
T519 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
Y522 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S523 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 17081983, ...17553757, 18669648, 19690332
S525 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 19690332, 20068231
K527 Acetylation PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
T543 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 19690332
T548 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 17081983
S552 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 17081983, ...15302935, 17553757, 21406692, 18669648, 24275569, 19690332, 20068231
S557 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S566 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 20068231
S580 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 17081983, ...20068231
T586 Phosphorylation PhosphoSitePlus
T591 Phosphorylation PhosphoSitePlus
T593 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
S625 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S630 Phosphorylation PhosphoSitePlus   UniProt 24275569
S635 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
S639 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S640 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S659 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S660 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S662 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T670 Phosphorylation PhosphoSitePlus   RLIMS-P 31135337
S674 Phosphorylation PhosphoSitePlus
K680 Sumoylation PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus   UniProt 24275569
T696 Phosphorylation PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus
S724 Phosphorylation PhosphoSitePlus
S727 Phosphorylation PhosphoSitePlus   UniProt 24275569
T750 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S751 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S754 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S755 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S765 Phosphorylation PhosphoSitePlus
S771 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243
S782 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S784 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   Signor 17525332, 12697768
S786 Phosphorylation PhosphoSitePlus
T804 Phosphorylation PhosphoSitePlus
K808 Ubiquitination PhosphoSitePlus
S809 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
Y812 Phosphorylation PhosphoSitePlus
T820 Phosphorylation PhosphoSitePlus
T823 Phosphorylation PhosphoSitePlus
S830 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S831 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17525332, 17553757, 22621922, ...15302935, 29328365, 18669648
S834 Phosphorylation PhosphoSitePlus   UniProt 23186163, 16964243, 19690332
T855 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 18669648
T859 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S860 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S862 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S867 Phosphorylation PhosphoSitePlus
K868 Sumoylation PhosphoSitePlus
K873 Ubiquitination PhosphoSitePlus
S876 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S877 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S892 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S894 Phosphorylation PhosphoSitePlus
S898 Phosphorylation PhosphoSitePlus
S899 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S900 Phosphorylation PhosphoSitePlus
T919 Phosphorylation PhosphoSitePlus
T922 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K930 Sumoylation PhosphoSitePlus
T938 Phosphorylation PhosphoSitePlus
T952 Phosphorylation PhosphoSitePlus
S970 Phosphorylation PhosphoSitePlus   UniProt 20068231
S975 Phosphorylation PhosphoSitePlus   UniProt 20068231
K984 Ubiquitination PhosphoSitePlus
S993 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T996 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S999 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1002 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K1009 Ubiquitination PhosphoSitePlus
T1012 Phosphorylation PhosphoSitePlus
T1020 Phosphorylation PhosphoSitePlus
S1025 Phosphorylation PhosphoSitePlus
S1028 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 17553757, 18669648, 19690332, 20068231
T1032 Phosphorylation PhosphoSitePlus
S1034 Phosphorylation PhosphoSitePlus
S1037 Phosphorylation PhosphoSitePlus
S1050 Phosphorylation PhosphoSitePlus
T1055 Phosphorylation PhosphoSitePlus
T1056 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163, 16964243
S1067 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1068 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 17081983, ...18669648, 20068231
S1086 Phosphorylation PhosphoSitePlus   UniProt 17553757
S1094 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S1101 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983
S1104 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S1113 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1114 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...17553757, 18669648, 24275569, 19690332, 20068231
T1122 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1148 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1156 Phosphorylation PhosphoSitePlus
S1160 Phosphorylation PhosphoSitePlus
R1162 Methylation PhosphoSitePlus
T1166 Phosphorylation PhosphoSitePlus
T1171 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K1175 Methylation PhosphoSitePlus
S1202 Phosphorylation PhosphoSitePlus
S1208 Phosphorylation PhosphoSitePlus
T1214 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 18669648, 17081983
S1216 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 17081983, ...18669648, 24275569
S1219 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17525332, 23186163, 17081983, ...22621922, 17553757, 18996087, 18669648
Y1258 Phosphorylation PhosphoSitePlus
Y1259 Phosphorylation PhosphoSitePlus
T1263 Phosphorylation PhosphoSitePlus
S1288 Phosphorylation PhosphoSitePlus
S1290 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
T1292 Phosphorylation PhosphoSitePlus
T1315 Phosphorylation PhosphoSitePlus
S1316 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S1317 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 23186163
T1319 Phosphorylation PhosphoSitePlus
S1320 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S1327 Phosphorylation PhosphoSitePlus
S1329 Phosphorylation PhosphoSitePlus
S1330 Phosphorylation PhosphoSitePlus
K1332 Acetylation PhosphoSitePlus
R1338 Methylation PhosphoSitePlus
K1340 Ubiquitination PhosphoSitePlus
T1341 Phosphorylation PhosphoSitePlus
S1342 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T1344 Phosphorylation PhosphoSitePlus
S1354 Phosphorylation PhosphoSitePlus
R1355 Methylation PhosphoSitePlus
K1360 Acetylation PhosphoSitePlus
S1362 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...22067460, 24275569, 23186163, 20068231
S1368 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T1370 Phosphorylation phospho.ELM 18669648
T1372 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
C1375 S-Nitrosylation dbSNO 26338901
K1390 Acetylation PhosphoSitePlus
T1394 Phosphorylation PhosphoSitePlus
R1396 Methylation PhosphoSitePlus
R1398 Methylation PhosphoSitePlus
R1400 Methylation PhosphoSitePlus
R1401 Methylation PhosphoSitePlus
R1403 Methylation PhosphoSitePlus
S1426 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...19690332, 20068231, 17081983
S1430 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 19690332, 20068231, 17081983
K1434 Sumoylation PhosphoSitePlus
S1435 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1437 Phosphorylation PhosphoSitePlus
T1450 Phosphorylation PhosphoSitePlus
S1460 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 17081983
S1462 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18669648, 19690332
S1474 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S1480 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1481 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1485 Phosphorylation PhosphoSitePlus
S1496 Phosphorylation PhosphoSitePlus
Y1500 Phosphorylation PhosphoSitePlus
K1505 Acetylation PhosphoSitePlus
K1516 Ubiquitination PhosphoSitePlus
Y1523 Phosphorylation PhosphoSitePlus
S1548 Phosphorylation PhosphoSitePlus
Y1552 Phosphorylation PhosphoSitePlus
S1554 Phosphorylation PhosphoSitePlus
K1559 Ubiquitination PhosphoSitePlus
K1563 Sumoylation PhosphoSitePlus
K1563 Ubiquitination PhosphoSitePlus
Y1569 Phosphorylation PhosphoSitePlus
K1574 Ubiquitination PhosphoSitePlus
Y1605 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1609 Phosphorylation P06493 (CDK1) , P24941 (CDK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 24703952, 25607646, ...18669648, 18847512, 20068231
T1612 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K1613 Ubiquitination PhosphoSitePlus
S1618 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 24703952, ...25607646, 18669648, 20068231
K1626 Acetylation PhosphoSitePlus
K1626 Methylation PhosphoSitePlus
K1626 Ubiquitination PhosphoSitePlus
S1631 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S1634 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340, 16094384
S1635 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16094384
T1638 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340, 16094384
T1640 Phosphorylation PhosphoSitePlus
S1642 Phosphorylation PhosphoSitePlus
S1643 Phosphorylation PhosphoSitePlus
S1644 Phosphorylation PhosphoSitePlus
S1645 Phosphorylation PhosphoSitePlus
S1646 Phosphorylation PhosphoSitePlus
T1647 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T1648 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1654 Phosphorylation PhosphoSitePlus
S1656 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1660 Phosphorylation PhosphoSitePlus
S1665 Phosphorylation PhosphoSitePlus
K1667 Acetylation PhosphoSitePlus
T1672 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1673 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S1678 Phosphorylation O14757 (CHEK1) , P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 17287340, 29603287, ...25607646, 18669648, 21851590, 23186163, 20068231, 17081983
S1686 Phosphorylation PhosphoSitePlus
K1690 Ubiquitination PhosphoSitePlus
S1701 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S1705 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T1709 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1713 Phosphorylation PhosphoSitePlus
S1749 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1756 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S1758 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S1759 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
K1773 Ubiquitination PhosphoSitePlus
S1778 Phosphorylation Q13315 (ATM) PRO   PhosphoSitePlus   RLIMS-P   UniProt 19876065, 19915695, 27494840, ...22421153, 19176521, 24583858, 21144835
S1929 Phosphorylation PhosphoSitePlus
K1960 Ubiquitination PhosphoSitePlus
K1966 Ubiquitination PhosphoSitePlus
S1971 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation Q13315 (ATM) HPRD 12697768
S25 Phosphorylation Q13315 (ATM) HPRD 12697768, 12447390
S29 Phosphorylation Q13315 (ATM) HPRD 12697768
S105 Phosphorylation HPRD 17525332
S119 Phosphorylation HPRD 18452278
S124 Phosphorylation HPRD 20068231
T214 Phosphorylation HPRD 20068231
S222 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
S259 Phosphorylation HPRD 17081983
S265 Phosphorylation HPRD 19413330, 17322306, 20058876, ...19664994, 18452278, 19651622, 18669648, 18767875, 20068231
S280 Phosphorylation HPRD 20068231
S287 Phosphorylation HPRD 20068230
S294 Phosphorylation HPRD 19413330, 15302935, 19664994, ...18452278, 19651622, 18669648, 20068231
S301 Phosphorylation HPRD 18452278
T302 Phosphorylation HPRD 17525332, 18077418, 18452278
T313 Phosphorylation HPRD 17081983
S315 Phosphorylation HPRD 17081983
S316 Phosphorylation HPRD 18669648, 15302935
S323 Phosphorylation HPRD 18669648, 17081983
S330 Phosphorylation HPRD 17081983
T337 Phosphorylation HPRD 17081983
T338 Phosphorylation HPRD 17081983
S345 Phosphorylation HPRD 17081983
S366 Phosphorylation HPRD 19651622, 20058876, 19664995, ...18707149
S379 Phosphorylation HPRD 17081983, 20058876, 19664995, ...18452278, 18669648, 20068231
S380 Phosphorylation HPRD 19413330, 17322306, 18767875, ...20058876, 19664995, 18452278, 19651622, 18669648, 19415658, 20068231
T382 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
T394 Phosphorylation HPRD 19413330, 20068231
S395 Phosphorylation HPRD 19413330, 19651622, 18669648
S398 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S482 Phosphorylation HPRD 20068231
T486 Phosphorylation HPRD 20068231
S490 Phosphorylation HPRD 20068231
T492 Phosphorylation HPRD 20068231
S493 Phosphorylation HPRD 18669648
S500 Phosphorylation HPRD 19413330, 17322306, 18212344, ...18767875, 19664994, 19664995, 18452278, 19651622, 18669648, 20068231
S507 Phosphorylation HPRD 17322306, 18767875
S518 Phosphorylation HPRD 19651622
T519 Phosphorylation HPRD 20068231
S520 Phosphorylation HPRD 19651622, 17081983, 20068231
Y522 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S523 Phosphorylation HPRD 19413330, 17525332, 18077418, ...18452278, 19651622, 18669648, 20068231
S525 Phosphorylation HPRD 19413330, 17322306, 20058876, ...18077418, 19664994, 19664995, 18452278, 19651622, 18669648, 19415658, 20068231
S533 Phosphorylation HPRD 17081983, 20068231
T543 Phosphorylation HPRD 17525332, 18077418
T548 Phosphorylation HPRD 17525332
S552 Phosphorylation HPRD 19413330, 18491316, 20058876, ...18077418, 15302935, 19664995, 18452278, 19651622, 18669648, 18707149, 19415658, 20068231
S557 Phosphorylation HPRD 18669648, 17081983, 18452278
S566 Phosphorylation HPRD 17525332, 18077418, 20068231
S580 Phosphorylation HPRD 19413330, 17525332, 18077418, ...18452278, 19651622, 20068231
T586 Phosphorylation HPRD 20068231
S625 Phosphorylation HPRD 17525332
S635 Phosphorylation HPRD 19413330, 17081983, 20068231
S639 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18452278
S640 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231, 18452278
S659 Phosphorylation HPRD 17081983
S660 Phosphorylation HPRD 17081983
S662 Phosphorylation HPRD 17081983
T670 Phosphorylation HPRD 17081983
S674 Phosphorylation HPRD 17081983
S724 Phosphorylation HPRD 20068231
S727 Phosphorylation HPRD 18452278
T750 Phosphorylation HPRD 17081983
S751 Phosphorylation HPRD 17081983
S754 Phosphorylation HPRD 17081983
S755 Phosphorylation HPRD 17081983
S771 Phosphorylation HPRD 19413330, 19664994, 19664995, ...18452278, 18669648, 19007248, 20068231
S782 Phosphorylation HPRD 15302935, 20068231
S784 Phosphorylation Q13315 (ATM) HPRD 12697768, 18077418
S809 Phosphorylation HPRD 19651622, 18669648, 19007248, ...20068231
S830 Phosphorylation HPRD 18669648, 20068231
S831 Phosphorylation HPRD 19413330, 15302935, 20058876, ...18452278, 18669648, 20068231
S834 Phosphorylation HPRD 16964243
T855 Phosphorylation HPRD 18077418, 17525332, 18669648, ...20068231
T859 Phosphorylation HPRD 18077418, 18669648
S860 Phosphorylation HPRD 18077418, 18669648
S862 Phosphorylation HPRD 18077418, 18669648
S876 Phosphorylation HPRD 18669648, 19007248, 20068231
S877 Phosphorylation HPRD 18669648, 20068231, 20068230
S888 Phosphorylation HPRD 17081983
S892 Phosphorylation HPRD 17525332
S899 Phosphorylation HPRD 20068231
S900 Phosphorylation HPRD 20068231
T902 Phosphorylation HPRD 17081983
T922 Phosphorylation HPRD 18669648, 20068231
S970 Phosphorylation HPRD 20068231
S975 Phosphorylation HPRD 20068231
S993 Phosphorylation HPRD 17081983
T996 Phosphorylation HPRD 17081983, 18452278
S999 Phosphorylation HPRD 19413330, 17081983
S1002 Phosphorylation HPRD 17081983
S1019 Phosphorylation HPRD 17081983
T1020 Phosphorylation HPRD 19413330, 17081983
S1025 Phosphorylation HPRD 19651622
S1028 Phosphorylation HPRD 19413330, 17322306, 18491316, ...18767875, 19664994, 19664995, 18452278, 19651622, 18669648, 20068231
S1050 Phosphorylation HPRD 17081983
T1055 Phosphorylation HPRD 19413330, 19664995
T1056 Phosphorylation HPRD 19413330, 16964243, 15302935, ...19664994, 19664995, 20068231
S1067 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S1068 Phosphorylation HPRD 17525332, 18077418, 18452278, ...19651622, 18669648, 18707149, 20068231
S1086 Phosphorylation HPRD 19651622, 17081983, 20068231
S1094 Phosphorylation HPRD 19651622, 18077418, 18669648, ...20068231, 17081983
S1101 Phosphorylation HPRD 19651622, 18077418, 18669648, ...20068231, 17081983
S1104 Phosphorylation HPRD 17525332, 18077418, 20068231
S1113 Phosphorylation HPRD 19413330, 17081983, 19664995, ...18452278, 18669648, 20068231
S1114 Phosphorylation HPRD 19413330, 17322306, 20058876, ...19664995, 18452278, 19651622, 18669648, 19415658, 20068231
T1122 Phosphorylation HPRD 18669648, 18452278
T1171 Phosphorylation HPRD 17525332
S1202 Phosphorylation HPRD 17081983, 20068231
S1208 Phosphorylation HPRD 17081983, 20068231
T1214 Phosphorylation HPRD 17525332, 18669648
S1216 Phosphorylation HPRD 19413330, 17525332, 18669648
S1219 Phosphorylation HPRD 19413330, 17525332, 18669648, ...20068231
S1288 Phosphorylation HPRD 18452278
S1290 Phosphorylation HPRD 17525332
T1315 Phosphorylation HPRD 17081983, 20068231
S1316 Phosphorylation HPRD 17287340, 17081983
S1317 Phosphorylation HPRD 19651622, 17287340, 17081983, ...20068231, 18452278
T1319 Phosphorylation HPRD 20068231
S1320 Phosphorylation HPRD 17287340, 20068231
S1329 Phosphorylation HPRD 18452278
S1330 Phosphorylation HPRD 18452278
S1342 Phosphorylation HPRD 18669648
T1344 Phosphorylation HPRD 20068231
S1362 Phosphorylation HPRD 19413330, 17322306, 17287340, ...18212344, 19007248, 18452278, 19651622, 18707149, 19415658, 20068231
S1368 Phosphorylation HPRD 18669648
T1370 Phosphorylation HPRD 18669648
T1372 Phosphorylation HPRD 18669648
S1426 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 20068231, 16964243
S1430 Phosphorylation HPRD 19413330, 16964243, 19664994, ...19664995, 18452278, 19651622, 18669648, 20068231, 17081983
S1435 Phosphorylation HPRD 18669648
T1450 Phosphorylation HPRD 20068231
S1460 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S1462 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S1474 Phosphorylation HPRD 18669648, 17081983, 20068231
S1480 Phosphorylation HPRD 18669648, 17081983
S1481 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
S1485 Phosphorylation HPRD 17081983
Y1605 Phosphorylation HPRD 18669648
T1609 Phosphorylation HPRD 18669648, 20068231
S1618 Phosphorylation HPRD 19413330, 17322306, 19664994, ...19007248, 18452278, 19651622, 18669648, 20068231
S1631 Phosphorylation HPRD 17287340
S1634 Phosphorylation HPRD 17287340, 19664995, 16094384
S1635 Phosphorylation HPRD 19413330, 16094384
T1638 Phosphorylation HPRD 19413330, 17287340, 19664995, ...16094384
T1640 Phosphorylation HPRD 19413330, 19664995
S1643 Phosphorylation HPRD 19664995
S1644 Phosphorylation HPRD 19664995, 20068231
S1645 Phosphorylation HPRD 19413330, 19664995
S1646 Phosphorylation HPRD 19413330, 19664995
T1647 Phosphorylation HPRD 19413330, 17287340, 19664995
T1648 Phosphorylation HPRD 19413330, 18491316, 19664995
T1654 Phosphorylation HPRD 20068231
S1656 Phosphorylation HPRD 20068231
S1665 Phosphorylation HPRD 20068231
T1672 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231
S1673 Phosphorylation HPRD 19413330, 17081983, 19664994, ...19664995, 19651622, 18669648, 20068231
S1678 Phosphorylation HPRD 19413330, 17322306, 17287340, ...19664995, 18452278, 19651622, 18669648, 19007248, 20068231
S1701 Phosphorylation HPRD 19413330, 18669648, 17081983
S1705 Phosphorylation HPRD 19413330, 17081983
T1709 Phosphorylation HPRD 18669648
S1749 Phosphorylation HPRD 18669648
T1756 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S1758 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S1759 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049527 (hTP53BP1/Phos:2) pS25,pS1778 PRO
PR:000049528 (hTP53BP1/SumoLys+) su PRO


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000027766 (hTP53/iso:1/Me2:1) Interaction PR:Q12888 (hTP53BP1) PRO 18840612


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S78 I78 Biomuta DOID:363 / uterine cancer [ tcga ]
T117 I117 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T117 K117 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:1324 / lung cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
S127 C127 Biomuta DOID:1324 / lung cancer [ cosmic ]
K135 R135 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K217 N217 Biomuta DOID:363 / uterine cancer [ tcga ]
S222 Y222 Biomuta DOID:3571 / liver cancer [ icgc ]
S287 I287 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S320 F320 Biomuta DOID:4362 / cervical cancer [ tcga ]
S320 C320 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S323 L323 Biomuta DOID:4159 / skin cancer [ icgc ]
S345 C345 Biomuta DOID:4362 / cervical cancer [ tcga ]
S359 Y359 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S359 F359 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc ]
S379 N379 Biomuta DOID:363 / uterine cancer [ tcga ]
S379 C379 Biomuta DOID:3571 / liver cancer [ icgc ]
T394 S394 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S452 C452 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S483 L483 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T486 K486 Biomuta DOID:3571 / liver cancer [ icgc ]
S490 F490 Biomuta DOID:1324 / lung cancer [ tcga ]
S523 N523 Biomuta DOID:363 / uterine cancer [ tcga ]
K527 N527 Biomuta DOID:363 / uterine cancer [ tcga ]
T548 M548 Biomuta DOID:263 / kidney cancer [ icgc, tcga ]
S635 F635 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S660 L660 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K680 * Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
S686 R686 Biomuta DOID:4159 / skin cancer [ icgc ]
S754 F754 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S755 I755 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
T804 S804 Biomuta DOID:1324 / lung cancer [ icgc ]
Y812 C812 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S831 L831 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S834 F834 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T855 I855 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S867 * Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S877 * Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S888 C888 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S894 R894 Biomuta DOID:1909 / melanoma [ cosmic ]
S975 F975 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S975 Y975 Biomuta DOID:3571 / liver cancer [ icgc ]
S1019 T1019 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1019 F1019 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1101 Y1101 Biomuta DOID:10534 / stomach cancer [ tcga ]
T1122 A1122 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
S1329 N1329 Biomuta DOID:363 / uterine cancer [ tcga ]
S1329 T1329 Biomuta DOID:3070 / malignant glioma [ tcga ]
R1338 K1338 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K1340 R1340 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S1354 C1354 Biomuta DOID:263 / kidney cancer [ tcga ]
R1355 P1355 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
R1355 * Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T1370 K1370 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K1390 N1390 Biomuta DOID:3070 / malignant glioma [ tcga ]
T1394 K1394 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T1394 M1394 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
R1396 C1396 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R1396 H1396 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
R1400 * Biomuta DOID:1909 / melanoma [ cosmic ]
R1400 Q1400 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1430 P1430 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y1523 H1523 Biomuta DOID:1909 / melanoma [ tcga ]
Y1523 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1554 N1554 Biomuta DOID:263 / kidney cancer [ cosmic ]
K1613 E1613 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1635 P1635 Biomuta DOID:0070003 / blastoma [ cosmic ]
S1643 G1643 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1665 L1665 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S1665 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S1758 R1758 Biomuta DOID:3571 / liver cancer [ icgc ]
S1929 L1929 Biomuta DOID:10534 / stomach cancer [ icgc ]
S1971 F1971 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ]