Protein Information

Cytoscape View


UniProt AC / UniProt ID Q04828 / AK1C1_HUMAN
Protein Name Aldo-keto reductase family 1 member C1
Gene Name Name: AKR1C1
Synonyms:DDH,DDH1;
Organism Homo sapiens (Human)

PRO ID PR:Q04828
DAG View
PRO Name aldo-keto reductase family 1 member C1 (human)
Definition An aldo-keto reductase family 1 member C1 that is encoded in the genome of human.
Short Label hAKR1C1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q04828 (AKR1C1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Acetylation PhosphoSitePlus
K4 Sumoylation PhosphoSitePlus
K4 Ubiquitination PhosphoSitePlus
Y5 Phosphorylation PhosphoSitePlus
K9 Acetylation PhosphoSitePlus
K9 Sumoylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
K39 Methylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
K75 Sumoylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K104 Sumoylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
Y110 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K131 Sumoylation PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
Y184 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
Y196 Phosphorylation PhosphoSitePlus
K201 Acetylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
K246 Acetylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K247 Acetylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K270 Acetylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
Y305 Phosphorylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
Y317 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K4 E4 Biomuta DOID:3571 / liver cancer [ tcga ]
K31 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K31 E31 Biomuta DOID:1324 / lung cancer [ cosmic ]
K33 T33 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K39 T39 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S51 Y51 Biomuta DOID:1612 / breast cancer [ tcga ]
Y55 C55 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K68 N68 Biomuta DOID:1324 / lung cancer [ tcga ]
Y110 H110 Biomuta DOID:363 / uterine cancer [ tcga ]
S208 * Biomuta DOID:9256 / colorectal cancer [ tcga ]
K270 N270 Biomuta DOID:1909 / melanoma [ cosmic ]