Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01860 / PO5F1_HUMAN
Protein Name POU domain, class 5, transcription factor 1
Gene Name Name: POU5F1
Synonyms:OCT3,OCT4,OTF3;
Organism Homo sapiens (Human)

PRO ID PR:Q01860
DAG View
PRO Name POU domain, class 5, transcription factor 1 (human)
Definition A POU domain, class 5, transcription factor 1 that is encoded in the genome of human.
Short Label hPOU5F1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01860 (POU5F1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus   RLIMS-P 21296877
T92 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
S111 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) PhosphoSitePlus   Signor   UniProt 23024368, 22474382
T116 Phosphorylation PhosphoSitePlus
T118 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 22474382
K123 Sumoylation PhosphoSitePlus
K140 Methylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K144 Acetylation PhosphoSitePlus
K144 Methylation PhosphoSitePlus
K151 Acetylation PhosphoSitePlus
K151 Methylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
K154 Methylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K156 Acetylation PhosphoSitePlus
K156 Methylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
T163 Phosphorylation PhosphoSitePlus
K177 Methylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
R186 Methylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
K195 Acetylation PhosphoSitePlus
K195 Methylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K199 Acetylation PhosphoSitePlus
K199 Methylation PhosphoSitePlus
K206 Methylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
T235 Phosphorylation P31751 (AKT2) , P31749 (AKT1) , Q9Y243 (AKT3) PhosphoSitePlus   RLIMS-P   Signor   UniProt 23041284, 22474382, 25625591, ...25116380
S236 Phosphorylation PhosphoSitePlus   UniProt 22474382
S288 Phosphorylation P11309 (PIM1) , P17612 (PRKACA) neXtProt   PhosphoSitePlus 22474382
S289 Phosphorylation P11309 (PIM1) , P17612 (PRKACA) neXtProt   PhosphoSitePlus   UniProt 22474382
S290 Phosphorylation PhosphoSitePlus   UniProt 22474382
Y292 Phosphorylation PhosphoSitePlus
T352 Phosphorylation PhosphoSitePlus
S355 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   UniProt 22474382
S359 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q01860 (POU5F1) T235 P48431 (SOX2) decreased_association eFIP 25116380


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
S111 F111 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S111 P111 Biomuta DOID:2994 / germ cell cancer [ tcga ]
K156 N156 Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T163 I163 Biomuta DOID:363 / uterine cancer [ tcga ]
K177 N177 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
R186 H186 Biomuta DOID:363 / uterine cancer [ tcga ]