Protein Information

Cytoscape View


UniProt AC / UniProt ID P98082 / DAB2_HUMAN
Protein Name Disabled homolog 2
Gene Name Name: DAB2
Synonyms:DOC2;
Organism Homo sapiens (Human)

PRO ID PR:P98082
DAG View
PRO Name disabled homolog 2 (human)
Definition A disabled homolog 2 that is encoded in the genome of human.
Short Label hDAB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P98082 (DAB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 Phosphorylation PhosphoSitePlus
S24 Phosphorylation Q05655 (PRKCD) , P05129 (PRKCG) , P05771-2 (PRKCB) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10542228, 11812785, 15280374, ...11371563
K34 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
R64 Methylation PhosphoSitePlus
K67 Acetylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
T151 Phosphorylation PhosphoSitePlus
K163 Methylation PhosphoSitePlus
Y170 Phosphorylation PhosphoSitePlus
K173 Methylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
T221 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S227 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 28876503, 15302935
T229 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S326 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S328 Phosphorylation PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
Y342 Phosphorylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
S393 Phosphorylation phospho.ELM   PhosphoSitePlus 16964243
S394 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 28876503, 18669648, 16964243
S401 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 16964243, 15302935, ...28876503, 18669648, 24275569, 20068231
S407 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
T437 Phosphorylation PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
S448 Phosphorylation RLIMS-P 25253241
S449 Phosphorylation RLIMS-P 25253241
S467 Phosphorylation PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
S675 Phosphorylation PhosphoSitePlus   UniProt 23186163
S684 Phosphorylation PhosphoSitePlus
Y685 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28876503, 23186163
K728 Ubiquitination PhosphoSitePlus
S729 Phosphorylation PhosphoSitePlus
T730 Phosphorylation PhosphoSitePlus
Y761 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation P05129 (PRKCG) , Q05655 (PRKCD) , P05771 (PRKCB) HPRD 10542228
T221 Phosphorylation HPRD 15302935
S227 Phosphorylation HPRD 15302935, 20068231
T229 Phosphorylation HPRD 20068231
S231 Phosphorylation HPRD 20068231
S324 Phosphorylation HPRD 20068231
S326 Phosphorylation HPRD 18669648
T329 Phosphorylation HPRD 20068231
Y342 Phosphorylation HPRD 17081983
S393 Phosphorylation HPRD 16964243, 20068231, 17081983
S394 Phosphorylation HPRD 19651622, 18669648, 16964243, ...20068231, 17081983
S401 Phosphorylation HPRD 17322306, 18491316, 16964243, ...18767875, 19664994, 19651622, 18669648, 20068231
S422 Phosphorylation HPRD 17081983, 20068231
T473 Phosphorylation HPRD 20068231
S723 Phosphorylation HPRD 18767875, 18212344, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P98082 (DAB2) S24 P05106 (ITGB3) unknown eFIP 15280374


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 F2 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S24 * Biomuta DOID:3571 / liver cancer [ icgc ]
R64 T64 Biomuta DOID:1324 / lung cancer [ cosmic ]
K77 * Biomuta DOID:1324 / lung cancer [ tcga ]
K120 M120 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T151 S151 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K163 I163 Biomuta DOID:1324 / lung cancer [ tcga ]
K173 N173 Biomuta DOID:363 / uterine cancer [ tcga ]
S208 L208 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]
S264 Y264 Biomuta DOID:363 / uterine cancer [ tcga ]
T307 A307 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S313 F313 Biomuta DOID:1909 / melanoma [ tcga ] DOID:5041 / esophageal cancer [ icgc ]
S313 C313 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S313 Y313 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]
S316 Y316 Biomuta DOID:363 / uterine cancer [ tcga ]
S324 L324 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]
S328 C328 Biomuta DOID:1324 / lung cancer [ tcga ]
S332 I332 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
Y342 F342 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y342 D342 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
S390 C390 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K392 R392 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S393 Y393 Biomuta DOID:2394 / ovarian cancer [ tcga ]
S401 R401 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S423 * Biomuta DOID:3571 / liver cancer [ icgc ]
S448 Y448 Biomuta DOID:363 / uterine cancer [ tcga ]
T473 K473 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S723 F723 Biomuta DOID:1909 / melanoma [ tcga ]
S723 P723 Biomuta DOID:1909 / melanoma [ tcga ]