Protein Information

Cytoscape View


UniProt AC / UniProt ID P80192 / M3K9_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 9
Gene Name Name: MAP3K9
Synonyms:MLK1,PRKE1;
Organism Homo sapiens (Human)

PRO ID PR:P80192
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 9 (human)
Definition A mitogen-activated protein kinase kinase kinase 9 that is encoded in the genome of human.
Short Label hMAP3K9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P80192 (MAP3K9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y110 Phosphorylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T304 Phosphorylation P80192 (MAP3K9) neXtProt   UniProt 15610029
T305 Phosphorylation P80192 (MAP3K9) neXtProt   UniProt 15610029
S308 Phosphorylation P80192 (MAP3K9) neXtProt   UniProt 15610029
T312 Phosphorylation P80192 (MAP3K9) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15610029
T452 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus   UniProt 23186163
T535 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
T554 Phosphorylation PhosphoSitePlus
T565 Phosphorylation PhosphoSitePlus
K594 Acetylation PhosphoSitePlus
K595 Acetylation PhosphoSitePlus
K607 Acetylation PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
K658 Ubiquitination PhosphoSitePlus
S693 Phosphorylation PhosphoSitePlus
S695 Phosphorylation PhosphoSitePlus
S807 Phosphorylation PhosphoSitePlus
T808 Phosphorylation PhosphoSitePlus
S809 Phosphorylation PhosphoSitePlus
S812 Phosphorylation PhosphoSitePlus
T915 Phosphorylation PhosphoSitePlus
S917 Phosphorylation PhosphoSitePlus
S938 Phosphorylation PhosphoSitePlus
T948 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T312 Phosphorylation P80192 (MAP3K9) HPRD 15610029
T529 Phosphorylation HPRD 18691976
S533 Phosphorylation HPRD 18691976
S547 Phosphorylation HPRD 18691976
S552 Phosphorylation HPRD 18691976
T565 Phosphorylation HPRD 18691976
S821 Phosphorylation HPRD 18691976
T822 Phosphorylation HPRD 18691976


P80192 (MAP3K9) as PTM Enzyme



Substrate Site Score Source PMID
P80192 (MAP3K9) T304 neXtProt   UniProt 15610029
P80192 (MAP3K9) T305 neXtProt   UniProt 15610029
P80192 (MAP3K9) S308 neXtProt   UniProt 15610029
P80192-4 (MAP3K9) T312 HPRD   neXtProt   UniProt 15610029


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T312 M312 Biomuta DOID:363 / uterine cancer [ tcga ]
S519 G519 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S533 T533 Biomuta DOID:3070 / malignant glioma [ tcga ]
S533 Y533 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S548 R548 Biomuta DOID:1612 / breast cancer [ tcga ]
T554 P554 Biomuta DOID:1612 / breast cancer [ icgc ]
K594 E594 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S616 F616 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S693 L693 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S917 F917 Biomuta DOID:1909 / melanoma [ icgc, tcga ]