Protein Information

Cytoscape View


UniProt AC / UniProt ID P63252 / KCNJ2_HUMAN
Protein Name Inward rectifier potassium channel 2
Gene Name Name: KCNJ2
Synonyms:IRK1;
Organism Homo sapiens (Human)

PRO ID PR:P63252
DAG View
PRO Name inward rectifier potassium channel 2 (human)
Definition An inward rectifier potassium channel 2 that is encoded in the genome of human.
Short Label hKCNJ2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P63252 (KCNJ2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 25043870
Y9 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
Y242 Phosphorylation PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
Y337 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
K338 Ubiquitination PhosphoSitePlus
Y341 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
Y366 Phosphorylation PhosphoSitePlus
S425 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 19843922


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
G2 D2 Biomuta DOID:363 / uterine cancer [ tcga ]
Y336 H336 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y341 N341 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S342 F342 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1909 / melanoma [ tcga ]