Protein Information

Cytoscape View


UniProt AC / UniProt ID P51654 / GPC3_HUMAN
Protein Name Glypican-3 precursor
Gene Name Name: GPC3
Synonyms:OCI5;
Organism Homo sapiens (Human)

PRO ID PR:P51654
DAG View
PRO Name glypican-3 (human)
Definition A glypican-3 that is encoded in the genome of human.
Short Label hGPC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51654 (GPC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K50 Ubiquitination PhosphoSitePlus
N124 N-Glycosylation GlyGen   UniProt 29345911
N241 N-Glycosylation GlyGen   UniProt 29345911
Y299 Phosphorylation PhosphoSitePlus
Y311 Phosphorylation PhosphoSitePlus
S352 Phosphorylation UniProt 26091039
S359 O-Glycosylation PhosphoSitePlus
N418 N-Glycosylation GlyGen   UniProt 29345911
K442 Ubiquitination PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T342 Phosphorylation PhosphoSitePlus
T343 Phosphorylation PhosphoSitePlus
T344 Phosphorylation PhosphoSitePlus
T346 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N124 D124 Biomuta DOID:363 / uterine cancer [ tcga ]
Y311 F311 Biomuta DOID:1324 / lung cancer [ cosmic ]
S359 P359 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S571 L571 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]