Protein Information

Cytoscape View


UniProt AC / UniProt ID P50750 / CDK9_HUMAN
Protein Name Cyclin-dependent kinase 9
Gene Name Name: CDK9
Synonyms:CDC2L4,TAK;
Organism Homo sapiens (Human)

PRO ID PR:P50750
DAG View
PRO Name cyclin-dependent kinase 9 (human)
Definition A cyclin-dependent kinase 9 that is encoded in the genome of human.
Short Label hCDK9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P50750 (CDK9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Acetylation PhosphoSitePlus
K3 Ubiquitination PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
K21 Methylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K24 Sumoylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
T29 Phosphorylation RLIMS-P 23140174
K35 Acetylation PhosphoSitePlus
K35 Methylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
K44 Acetylation PhosphoSitePlus   UniProt 18250157, 17452463
K44 Ubiquitination PhosphoSitePlus
K48 Acetylation PhosphoSitePlus   UniProt 18250157, 28426094
K49 Acetylation PhosphoSitePlus
K49 Sumoylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K56 Acetylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
R86 Methylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
S90 Phosphorylation P24941 (CDK2) PhosphoSitePlus   RLIMS-P 24524087, 23140174, 26178009
K127 Acetylation PhosphoSitePlus
K127 Methylation PhosphoSitePlus
K151 Sumoylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K164 Acetylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
S175 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23140174, 29743242, 26178009, ...16109377, 21533037, 23658523, 28178316
K178 Acetylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S180 Phosphorylation RLIMS-P 21533037
T186 Phosphorylation P50750 (CDK9) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 23152527, 23140174, 18829461, ...18483222, 17192257, 29095844, 20201073, 21448926, 15965233, 22727189, 21098020, 25909811, 29792216, 16048649, 26178009, 20851342, 21533037, 23658523, 28178316, 27918433, 18566585, 26727990, 21406692, 23064645, 19741158, 28539972, 24528253, 14627702, 20535204, 28878233, 21779453
K269 Acetylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K274 Acetylation PhosphoSitePlus
K276 Acetylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
S329 Phosphorylation RLIMS-P 16048649
T330 Phosphorylation RLIMS-P 16048649
T333 Phosphorylation RLIMS-P 16048649
S334 Phosphorylation RLIMS-P 16048649
Y338 Phosphorylation PhosphoSitePlus
K345 Acetylation PhosphoSitePlus
K345 Methylation PhosphoSitePlus
K345 Sumoylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
S347 Phosphorylation P50750 (CDK9) PhosphoSitePlus   RLIMS-P   UniProt 18566585, 18691976, 19369195, ...16048649, 24275569, 10958691
T350 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 19369195, 16048649, 10958691
S353 Phosphorylation P50750 (CDK9) PhosphoSitePlus   RLIMS-P   UniProt 10958691, 16048649
T354 Phosphorylation P50750 (CDK9) PhosphoSitePlus   RLIMS-P   UniProt 10958691, 16048649
S357 Phosphorylation PhosphoSitePlus   UniProt 10958691
T362 Phosphorylation P50750 (CDK9) PhosphoSitePlus   UniProt 18566585
T363 Phosphorylation P50750 (CDK9) PhosphoSitePlus   UniProt 18566585
T366 Phosphorylation PhosphoSitePlus
R370 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K44 Acetylation PR:Q09472 (hEP300) , PR:000007902 (KAT2A) , PR:000012332 (KAT2B) , PR:000007102 (EP300) PRO 18250157, 17452463
K48 Acetylation PR:000012332 (KAT2B) , PR:000007902 (KAT2A) , PR:000007102 (EP300) PRO 18250157
S180 Phosphorylation HPRD 18691976
T186 Phosphorylation HPRD 19651622, 18691976, 20068231
T330 Phosphorylation HPRD 17081983
T333 Phosphorylation HPRD 17081983
S334 Phosphorylation HPRD 17081983
S347 Phosphorylation HPRD 19651622, 18691976
S353 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
R8 Methylation PhosphoSitePlus
R15 Methylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus
T55 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
R74 Methylation PhosphoSitePlus
R87 Methylation PhosphoSitePlus
K391 Acetylation PhosphoSitePlus
K393 Acetylation PhosphoSitePlus


P50750 (CDK9) as PTM Enzyme



Substrate Site Score Source PMID
O00267 (SUPT5H) S666 PhosphoSitePlus 26728557
O00267 (SUPT5H) T768 PhosphoSitePlus   Signor 16427012
O00267 (SUPT5H) T775 PhosphoSitePlus   Signor 16427012
O00267 (SUPT5H) T784 PhosphoSitePlus   Signor 16427012
O00267 (SUPT5H) T791 PhosphoSitePlus   Signor 16427012
O00267 (SUPT5H) T799 PhosphoSitePlus   Signor 16427012
O00267 (SUPT5H) T806 PhosphoSitePlus   Signor 26728557, 16427012
O00267 (SUPT5H) T814 PhosphoSitePlus   Signor 16427012
P04637 (TP53) S33 HPRD   PhosphoSitePlus   Signor 17942552, 16552184
P04637-1 (TP53) S315 HPRD   PhosphoSitePlus   Signor 19413330, 17287340, 16552184, ...19664995, 12064478, 10884347, 24173284
P04637 (TP53) S392 HPRD   PhosphoSitePlus   RLIMS-P+   Signor 19413330, 10747897, 16552184, ...10348343, 10884347, 16741955, 23603988
P06400 (RB1) S795 PhosphoSitePlus 12037672
P06400 (RB1) S807 PhosphoSitePlus 12037672
P06400 (RB1) S811 PhosphoSitePlus 12037672
P24928 (POLR2A) S1616 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 22053051, 17259211, 23249733, ...20106982, 14662762, 19575011, 24385927, 10958691, 25561469
P24928 (POLR2A) T1618 neXtProt   PhosphoSitePlus 22053051
P24928 (POLR2A) S1619 PhosphoSitePlus 26748711, 17259211, 24662513, ...10958691, 19901026, 10364292, 25561469
P24928 (POLR2A) S1621 PhosphoSitePlus 26748711, 24662513, 19901026, ...25561469
P24928 (POLR2A) S1623 Signor 24385927
P24928 (POLR2A) S1644 Signor 24385927
P24928 (POLR2A) S1651 Signor 24385927
P24928 (POLR2A) S1665 Signor 24385927
P24928 (POLR2A) S1672 Signor 24385927
P24928 (POLR2A) S1693 Signor 24385927
P24928 (POLR2A) S1714 Signor 24385927
P24928 (POLR2A) S1721 Signor 24385927
P24928 (POLR2A) S1735 Signor 24385927
P24928 (POLR2A) S1763 Signor 24385927
P24928 (POLR2A) S1784 Signor 24385927
P24928 (POLR2A) S1861 Signor 24385927
P24928 (POLR2A) S1868 Signor 24385927
P24928 (POLR2A) S1875 Signor 24385927
P24928 (POLR2A) S1878 Signor 24385927
P24928 (POLR2A) S1882 Signor 24385927
P24928 (POLR2A) S1889 Signor 24385927
P24928 (POLR2A) S1896 Signor 24385927
P24928 (POLR2A) S1910 Signor 24385927
P24928 (POLR2A) S1917 Signor 24385927
P24928 (POLR2A) S1924 Signor 24385927
P24928 (POLR2A) S1931 Signor 24385927
P24928 (POLR2A) S1941 Signor 24385927
P24928 (POLR2A) S1948 Signor 24385927
P37231 (PPARG) S112 PhosphoSitePlus 17998334
P50750 (CDK9) T186 PhosphoSitePlus   RLIMS-P+ 18566585, 19741158
P50750 (CDK9) S347 PhosphoSitePlus 18566585, 10958691
P50750 (CDK9) S353 PhosphoSitePlus 10958691
P50750 (CDK9) T354 PhosphoSitePlus 10958691
P50750 (CDK9) T362 PhosphoSitePlus 18566585
P50750 (CDK9) T363 PhosphoSitePlus 18566585
P84022 (SMAD3) T179 PhosphoSitePlus   Signor 19914161, 19914168
P84022 (SMAD3) S208 PhosphoSitePlus   Signor 19914161, 19914168
P84022 (SMAD3) S213 PhosphoSitePlus   Signor 19914161, 19914168
Q02539 (H1-1) S183 PhosphoSitePlus 20551309
Q15596 (NCOA2) S469 PhosphoSitePlus   Signor 22158970, 29170386
Q15596 (NCOA2) S487 PhosphoSitePlus   Signor 22158970, 29170386
Q15596 (NCOA2) S493 PhosphoSitePlus   Signor 22158970, 29170386
Q15596 (NCOA2) S499 PhosphoSitePlus   Signor 22158970, 29170386
Q15797 (SMAD1) S187 PhosphoSitePlus   Signor 19914161, 19914168
Q15797 (SMAD1) S195 PhosphoSitePlus   Signor 19914161, 19914168
Q15797 (SMAD1) S206 PhosphoSitePlus   Signor 19914161, 19914168
Q15797 (SMAD1) S214 PhosphoSitePlus   Signor 19914161, 19914168
Q6PGQ7 (BORA) S325 PhosphoSitePlus 25742493
Q96PM5 (RCHY1) S211 PhosphoSitePlus   Signor 23603988
Q96PM5 (RCHY1) T217 PhosphoSitePlus   Signor 23603988
Q9H0D6 (XRN2) T439 PhosphoSitePlus 26728557


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000027934 (hCDK9/iso:1/Ac:1) acK44 PR:Q09472 (hEP300) PRO 17452463
PR:000028670 (hCDK9/iso:1/Ac:2) acK44,acK48 PR:000007902 (KAT2A) PRO 18250157
PR:000028670 (hCDK9/iso:1/Ac:2) acK44,acK48 PR:000012332 (KAT2B) PRO 18250157
PR:000028670 (hCDK9/iso:1/Ac:2) acK44,acK48 PR:000007102 (EP300) PRO 18250157


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O60885 (BRD4) T204 P50750 (CDK9) unknown eFIP 28481868
Phosphorylation P04608 (tat) S16 P50750 (CDK9) unknown eFIP 29792216


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 L7 Biomuta DOID:1324 / lung cancer [ cosmic ]
R86 Q86 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
R86 L86 Biomuta DOID:3571 / liver cancer [ icgc ]
K127 R127 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R370 H370 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] DOID:1909 / melanoma [ cosmic ]