Protein Information

Cytoscape View

UniProt AC / UniProt ID P42765 / THIM_HUMAN
Protein Name 3-ketoacyl-CoA thiolase, mitochondrial
Gene Name Name: ACAA2
Organism Homo sapiens (Human)

PRO ID PR:P42765
DAG View
PRO Name 3-ketoacyl-CoA thiolase, mitochondrial (human)
Definition A 3-ketoacyl-CoA thiolase, mitochondrial that is encoded in the genome of human.
Short Label hACAA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P42765 (ACAA2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K13 Acetylation PhosphoSitePlus
Y20 Phosphorylation PhosphoSitePlus
K25 Acetylation PhosphoSitePlus
K38 Acetylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus
K81 Acetylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
T119 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S121 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y127 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
K137 Acetylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus   UniProt 24275569
K181 Acetylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
Y198 Phosphorylation PhosphoSitePlus
K234 Acetylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K240 Acetylation PhosphoSitePlus
K241 Acetylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K269 Acetylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K270 Acetylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
K305 Acetylation PhosphoSitePlus
K306 Acetylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus   UniProt 24275569
S339 Phosphorylation PhosphoSitePlus
R370 Methylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K13 R13 Biomuta DOID:3070 / malignant glioma [ tcga ]
T87 P87 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K269 N269 Biomuta DOID:1612 / breast cancer [ tcga ]
K270 * Biomuta DOID:1612 / breast cancer [ tcga ]