Protein Information

Cytoscape View


UniProt AC / UniProt ID P36873 / PP1G_HUMAN
Protein Name Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Gene Name Name: PPP1CC
Organism Homo sapiens (Human)

PRO ID PR:P36873
DAG View
PRO Name serine/threonine-protein phosphatase PP1-gamma catalytic subunit (human)
Definition A serine/threonine-protein phosphatase PP1-gamma catalytic subunit that is encoded in the genome of human.
Short Label hPPP1CC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P36873 (PPP1CC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 25944712
K6 Ubiquitination PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
R36 Methylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K113 Acetylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
R122 Methylation PhosphoSitePlus
C127 S-Nitrosylation dbSNO 19483679
S129 Phosphorylation PhosphoSitePlus
R132 Methylation PhosphoSitePlus
Y134 Phosphorylation PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K147 Acetylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
C155 S-Nitrosylation dbSNO 19483679
C158 S-Nitrosylation dbSNO 19483679
S177 Phosphorylation PhosphoSitePlus
K238 Acetylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
C245 S-Nitrosylation dbSNO 19483679
Y255 Phosphorylation PhosphoSitePlus
K260 Acetylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
T307 Phosphorylation P51955 (NEK2) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 10880350
T311 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T318 Phosphorylation P51955 (NEK2) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10880350
K319 Ubiquitination PhosphoSitePlus
K322 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T307 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T311 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S22 Y22 Biomuta DOID:3571 / liver cancer [ icgc ]
S22 P22 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R36 K36 Biomuta DOID:1324 / lung cancer [ icgc ]
R122 K122 Biomuta DOID:1612 / breast cancer [ tcga ]
C127 Y127 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S129 N129 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y137 F137 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
T307 M307 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T311 K311 Biomuta DOID:3571 / liver cancer [ icgc ]
K319 R319 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]