Protein Information

Cytoscape View


UniProt AC / UniProt ID P33981 / TTK_HUMAN
Protein Name Dual specificity protein kinase TTK
Gene Name Name: TTK
Synonyms:MPS1,MPS1L1;
Organism Homo sapiens (Human)

PRO ID PR:P33981
DAG View
PRO Name dual specificity protein kinase TTK (human)
Definition A dual specificity protein kinase TTK that is encoded in the genome of human.
Short Label hTTK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P33981 (TTK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19369195, 22814378
S3 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
T12 Phosphorylation P33981 (TTK) PhosphoSitePlus   RLIMS-P 25265012, 18923149
S15 Phosphorylation P33981 (TTK) PhosphoSitePlus   RLIMS-P 25265012, 18923149
K19 Methylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K28 Sumoylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
T33 Phosphorylation P33981 (TTK) PhosphoSitePlus   RLIMS-P   UniProt 18691976, 18545697, 23186163, ...19369195, 18669648, 18923149, 24256217, 20068231
S37 Phosphorylation P33981 (TTK) PhosphoSitePlus   RLIMS-P   UniProt 18691976, 18923149, 18545697, ...24256217, 20068231
T46 Phosphorylation PhosphoSitePlus
K71 Sumoylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
S80 Phosphorylation P33981 (TTK) PhosphoSitePlus   RLIMS-P   UniProt 18545697, 18923149, 18691976, ...22187426, 21778823
K86 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
T210 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
Y255 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
S281 Phosphorylation P15056 (BRAF) PhosphoSitePlus   RLIMS-P   UniProt 18691976, 22430208, 20068231, ...19369195
K287 Sumoylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
T288 Phosphorylation O96017 (CHEK2) , P33981 (TTK) PhosphoSitePlus   RLIMS-P   Signor 26531827, 18923149, 19151762, ...24764296
S291 Phosphorylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus   UniProt 18691976
S321 Phosphorylation PhosphoSitePlus   UniProt 19369195, 18669648, 23186163
K328 Ubiquitination PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
T351 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
T360 Phosphorylation P33981 (TTK) PhosphoSitePlus 18545697, 18923149
S362 Phosphorylation P33981 (TTK) PhosphoSitePlus 18923149
S363 Phosphorylation P33981 (TTK) PhosphoSitePlus 18545697, 18923149
K367 Sumoylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
T371 Phosphorylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
K385 Methylation PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus   UniProt 18691976, 18669648
K415 Ubiquitination PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
S436 Phosphorylation P15056 (BRAF) , P33981 (TTK) PhosphoSitePlus   RLIMS-P   UniProt 18691976, 18545697, 23186163, ...26714015, 19369195, 22430208
S440 Phosphorylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
T453 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus   UniProt 23186163
T458 Phosphorylation PhosphoSitePlus
Y462 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
R467 Methylation PhosphoSitePlus
T468 Phosphorylation PhosphoSitePlus   RLIMS-P 17804818
K472 Sumoylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus
T564 Phosphorylation P33981 (TTK) PhosphoSitePlus   RLIMS-P 21533207, 18680479
K577 Ubiquitination PhosphoSitePlus
S582 Phosphorylation P33981 (TTK) PhosphoSitePlus   Signor 18680479
K584 Ubiquitination PhosphoSitePlus
T594 Phosphorylation PhosphoSitePlus
K617 Ubiquitination PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
K649 Ubiquitination PhosphoSitePlus
T675 Phosphorylation P33981 (TTK) PhosphoSitePlus   RLIMS-P   Signor 26354417, 18923149, 18680479, ...19120698
T676 Phosphorylation P33981 (TTK) PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor 18545697, 18083840, 21587233, ...26354417, 22187426, 7678926, 18680479, 19120698, 20422024
S677 Phosphorylation P33981 (TTK) PhosphoSitePlus   RLIMS-P   Signor 18923149, 19120698
K680 Ubiquitination PhosphoSitePlus
S682 Phosphorylation RLIMS-P 21533207
T686 Phosphorylation P33981 (TTK) PhosphoSitePlus   RLIMS-P   Signor 18545697, 29502948, 26354417, ...22187426, 18680479, 19120698, 18923149
K696 Ubiquitination PhosphoSitePlus
K708 Methylation PhosphoSitePlus
S742 Phosphorylation P33981 (TTK) PhosphoSitePlus   RLIMS-P   Signor 21533207, 18680479
K762 Ubiquitination PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
T795 Phosphorylation P33981 (TTK) PhosphoSitePlus 18680479
K803 Ubiquitination PhosphoSitePlus
T805 Phosphorylation P33981 (TTK) PhosphoSitePlus 18680479
T806 Phosphorylation P33981 (TTK) PhosphoSitePlus   Signor 18680479
K810 Ubiquitination PhosphoSitePlus
Y811 Phosphorylation P33981 (TTK) PhosphoSitePlus 18680479
S821 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) , P33981 (TTK) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19369195, 29502948, 23186163, ...18691976, 18545697, 22187426, 18680479, 18787396, 18669648, 27633003, 20068231, 17924679
S824 Phosphorylation P33981 (TTK) PhosphoSitePlus 18680479
K827 Ubiquitination PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
Y833 Phosphorylation PhosphoSitePlus
Y836 Phosphorylation PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus
S845 Phosphorylation P33981 (TTK) PhosphoSitePlus 18680479
S847 Phosphorylation P33981 (TTK) PhosphoSitePlus 18680479
K848 Ubiquitination PhosphoSitePlus
T849 Phosphorylation P33981 (TTK) PhosphoSitePlus 18680479
K852 Acetylation PhosphoSitePlus
K853 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 18691976
T33 Phosphorylation HPRD 18691976, 18669648, 20068231, ...18452278
S37 Phosphorylation HPRD 18691976, 20068231
S49 Phosphorylation HPRD 18691976, 20068231
S80 Phosphorylation HPRD 18691976
S281 Phosphorylation HPRD 19413330, 18691976, 19664994, ...19664995, 17322306, 18669648, 20068231
S317 Phosphorylation HPRD 18691976
S321 Phosphorylation HPRD 18669648
S345 Phosphorylation HPRD 18691976
T351 Phosphorylation HPRD 18691976
S353 Phosphorylation HPRD 18691976
S393 Phosphorylation HPRD 18691976, 18669648, 20068231
S433 Phosphorylation HPRD 18691976, 20068231
S436 Phosphorylation HPRD 18691976, 19007248, 20068231
S455 Phosphorylation HPRD 18669648
T468 Phosphorylation P24941 (CDK2) phospho.ELM 17804818
T676 Phosphorylation P33981 (TTK) phospho.ELM   PRO 18545697, 18083840, 18680479, ...19120698
T686 Phosphorylation P33981 (TTK) phospho.ELM 18680479, 19120698
S821 Phosphorylation HPRD 19413330, 18691976, 19664995, ...18669648, 20068231, 17924679
S824 Phosphorylation HPRD 18669648, 17924679
Y833 Phosphorylation HPRD 18691976


P33981 (TTK) as PTM Enzyme



Substrate Site Score Source PMID
O60566 (BUB1B) S435 PhosphoSitePlus 19015317
O60566 (BUB1B) S543 PhosphoSitePlus 19015317
O60566 (BUB1B) S670 PhosphoSitePlus 19015317
O60566 (BUB1B) S1043 PhosphoSitePlus 19015317
O96017 (CHEK2) T68 phospho.ELM   PhosphoSitePlus   Signor 15618221
P00519 (ABL1) T735 phospho.ELM   PhosphoSitePlus   Signor 18794806
P04637 (TP53) T18 phospho.ELM   Signor 19332559
P07900 (HSP90AA1) T115 PhosphoSitePlus 26804907
P33981 (TTK) T12 PhosphoSitePlus 18923149
P33981 (TTK) S15 PhosphoSitePlus 18923149
P33981 (TTK) T33 PhosphoSitePlus 18545697, 18923149
P33981 (TTK) S37 PhosphoSitePlus 18545697, 18923149
P33981 (TTK) S80 PhosphoSitePlus 18545697, 18923149
P33981 (TTK) T288 PhosphoSitePlus 18923149, 19151762
P33981 (TTK) T360 PhosphoSitePlus 18545697, 18923149
P33981 (TTK) S362 PhosphoSitePlus 18923149
P33981 (TTK) S363 PhosphoSitePlus 18545697, 18923149
P33981 (TTK) S436 PhosphoSitePlus 18545697
P33981 (TTK) T564 PhosphoSitePlus 18680479
P33981 (TTK) S582 PhosphoSitePlus   Signor 18680479
P33981 (TTK) T675 PhosphoSitePlus   Signor 18923149, 18680479, 19120698
P33981 (TTK) T676 phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 18545697, 18083840, 26354417, ...22187426, 7678926, 18680479, 19120698
P33981 (TTK) S677 PhosphoSitePlus   Signor 18923149, 19120698
P33981 (TTK) T686 phospho.ELM   PhosphoSitePlus   Signor 18545697, 22187426, 18923149, ...18680479, 19120698
P33981 (TTK) S742 PhosphoSitePlus   Signor 18680479
P33981 (TTK) T795 PhosphoSitePlus 18680479
P33981 (TTK) T805 PhosphoSitePlus 18680479
P33981 (TTK) T806 PhosphoSitePlus   Signor 18680479
P33981 (TTK) Y811 PhosphoSitePlus 18680479
P33981 (TTK) S821 PhosphoSitePlus 18545697, 18680479
P33981 (TTK) S824 PhosphoSitePlus 18680479
P33981 (TTK) S845 PhosphoSitePlus 18680479
P33981 (TTK) S847 PhosphoSitePlus 18680479
P33981 (TTK) T849 PhosphoSitePlus 18680479
P38646 (HSPA9) T62 phospho.ELM   PhosphoSitePlus   Signor 17573779
P38646 (HSPA9) S65 phospho.ELM   PhosphoSitePlus   Signor 17573779
P54132 (BLM) S144 PhosphoSitePlus 16864798
P54132 (BLM) S1290 PhosphoSitePlus 16864798
P54132 (BLM) S1296 PhosphoSitePlus 16864798
Q53HL2 (CDCA8) T88 phospho.ELM   PhosphoSitePlus   Signor 19530738, 18243099
Q53HL2 (CDCA8) T94 phospho.ELM   PhosphoSitePlus   Signor 19530738, 18243099
Q53HL2 (CDCA8) T169 phospho.ELM   PhosphoSitePlus   Signor 19530738, 18243099
Q53HL2 (CDCA8) T230 phospho.ELM   PhosphoSitePlus   Signor 19530738, 18243099
Q53HL2 (CDCA8) S238 PhosphoSitePlus 19530738
Q96E14 (RMI2) S112 PhosphoSitePlus 24108125


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045754 (hTTK/Phos:1) pT676 PRO 18083840, 18680479, 19120698


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O14641 (hDVL2) Interaction PR:P33981 (hTTK) PRO 20823832
PR:P33981 (hTTK) Interaction PRO 22660415
PR:P33981 (hTTK) Interaction PR:Q12834 (hCDC20) PRO
PR:P33981 (hTTK) Interaction PRO 20624902


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 V1 Biomuta DOID:10283 / prostate cancer [ cosmic ]
M1 I1 Biomuta DOID:363 / uterine cancer [ tcga ]
T12 R12 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T46 A46 Biomuta DOID:1324 / lung cancer [ tcga ]
S49 A49 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K71 N71 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K102 T102 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S108 I108 Biomuta DOID:8618 / oral cavity cancer [ icgc ] DOID:0060119 / pharynx cancer [ cosmic ]
K140 N140 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K140 Q140 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K163 E163 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S214 * Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S218 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K266 E266 Biomuta DOID:363 / uterine cancer [ tcga ]
T288 I288 Biomuta DOID:1909 / melanoma [ tcga ]
S291 L291 Biomuta DOID:1324 / lung cancer [ tcga ]
S317 I317 Biomuta DOID:1115 / sarcoma [ tcga ]
S317 C317 Biomuta DOID:5041 / esophageal cancer [ icgc ]
K328 N328 Biomuta DOID:3571 / liver cancer [ icgc ]
K336 N336 Biomuta DOID:363 / uterine cancer [ tcga ]
S345 I345 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S345 N345 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T360 K360 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K392 N392 Biomuta DOID:3571 / liver cancer [ icgc ]
K452 N452 Biomuta DOID:1324 / lung cancer [ cosmic ]
T458 A458 Biomuta DOID:1909 / melanoma [ cosmic ]
S464 I464 Biomuta DOID:3571 / liver cancer [ icgc ]
T468 A468 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K472 N472 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ]
K546 N546 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
K553 T553 Biomuta DOID:363 / uterine cancer [ tcga ]
K577 * Biomuta DOID:1324 / lung cancer [ tcga ]
S582 G582 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S582 I582 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1324 / lung cancer [ tcga ]
T594 M594 Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:263 / kidney cancer [ tcga ]
S618 F618 Biomuta DOID:1909 / melanoma [ tcga ]
T675 K675 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T676 A676 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S677 R677 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S677 G677 Biomuta DOID:363 / uterine cancer [ tcga ]
S742 Y742 Biomuta DOID:363 / uterine cancer [ tcga ]
K803 N803 Biomuta DOID:1324 / lung cancer [ tcga ]
S821 Y821 Biomuta DOID:363 / uterine cancer [ tcga ]
S824 F824 Biomuta DOID:1909 / melanoma [ tcga ]