Protein Information

Cytoscape View


UniProt AC / UniProt ID P32019 / I5P2_HUMAN
Protein Name Type II inositol 1,4,5-trisphosphate 5-phosphatase precursor
Gene Name Name: INPP5B
Synonyms:OCRL2;
Organism Homo sapiens (Human)

PRO ID PR:P32019
DAG View
PRO Name type II inositol 1,4,5-trisphosphate 5-phosphatase (human)
Definition A type II inositol 1,4,5-trisphosphate 5-phosphatase that is encoded in the genome of human.
Short Label hINPP5B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P32019 (INPP5B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S116 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
Y432 Phosphorylation PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
T586 Phosphorylation PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
K630 Ubiquitination PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
T651 Phosphorylation PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
Y684 Phosphorylation PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
S961 Phosphorylation PhosphoSitePlus
K972 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y352 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K415 Q415 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K496 N496 Biomuta DOID:363 / uterine cancer [ tcga ]
T586 M586 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:263 / kidney cancer [ icgc, tcga ]
T586 K586 Biomuta DOID:1324 / lung cancer [ tcga ]
K630 T630 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K650 M650 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K661 Q661 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K674 * Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]