Protein Information

Cytoscape View

UniProt AC / UniProt ID P23368 / MAOM_HUMAN
Protein Name NAD-dependent malic enzyme, mitochondrial precursor
Gene Name Name: ME2
Organism Homo sapiens (Human)

PRO ID PR:P23368
DAG View
PRO Name NAD-dependent malic enzyme, mitochondrial (human)
Definition An NAD-dependent malic enzyme, mitochondrial that is encoded in the genome of human.
Short Label hME2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P23368 (ME2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K24 Acetylation PhosphoSitePlus
R67 Methylation PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
T113 O-Glycosylation GlyGen 29351928
T115 O-Glycosylation GlyGen 29351928
K156 Acetylation PhosphoSitePlus   UniProt 19608861
Y175 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
K224 Acetylation PhosphoSitePlus   UniProt 19608861
K240 Acetylation PhosphoSitePlus   UniProt 19608861
Y269 Phosphorylation PhosphoSitePlus
K272 Acetylation PhosphoSitePlus   UniProt 19608861
T283 Phosphorylation PhosphoSitePlus
K339 Acetylation PhosphoSitePlus
K346 Acetylation PhosphoSitePlus   UniProt 19608861
K346 Ubiquitination PhosphoSitePlus
Y347 Phosphorylation PhosphoSitePlus
T400 Phosphorylation PhosphoSitePlus
C441 S-Nitrosylation dbSNO 19483679
K453 Ubiquitination PhosphoSitePlus
T503 Phosphorylation PhosphoSitePlus
Y533 Phosphorylation PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
Y543 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R67 Q67 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
R67 G67 Biomuta DOID:1324 / lung cancer [ cosmic ]
S106 I106 Biomuta DOID:3571 / liver cancer [ icgc ]
Y269 H269 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y269 C269 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
T283 I283 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K339 N339 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K346 M346 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y347 * Biomuta DOID:11934 / head and neck cancer [ tcga ]
Y543 C543 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]