Protein Information

Cytoscape View


UniProt AC / UniProt ID P20930 / FILA_HUMAN
Protein Name Filaggrin
Gene Name Name: FLG
Organism Homo sapiens (Human)

PRO ID PR:P20930
DAG View
PRO Name filaggrin (human)
Definition A filaggrin that is encoded in the genome of human.
Short Label hFLG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P20930 (FLG) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y18 Phosphorylation PhosphoSitePlus
Y85 Phosphorylation PhosphoSitePlus
Y86 Phosphorylation PhosphoSitePlus
S127 Phosphorylation HPRD   PhosphoSitePlus 20068231
T147 Phosphorylation PhosphoSitePlus
Y164 Phosphorylation HPRD 18691976
S165 Phosphorylation HPRD 20068231
T167 Phosphorylation HPRD 20068231
Y215 Phosphorylation PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
Y236 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
R343 Methylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
T434 Phosphorylation PhosphoSitePlus
Y470 Phosphorylation PhosphoSitePlus
T515 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
T581 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
S640 Phosphorylation PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
S702 Phosphorylation PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
Y795 Phosphorylation PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
S848 Phosphorylation PhosphoSitePlus
S944 Phosphorylation PhosphoSitePlus
S945 Phosphorylation PhosphoSitePlus
S950 Phosphorylation PhosphoSitePlus
S956 Phosphorylation PhosphoSitePlus
S959 Phosphorylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus
T1012 Phosphorylation PhosphoSitePlus
S1013 Phosphorylation PhosphoSitePlus
S1014 Phosphorylation PhosphoSitePlus
S1020 Phosphorylation PhosphoSitePlus
S1021 Phosphorylation PhosphoSitePlus
S1055 Phosphorylation PhosphoSitePlus
S1114 Phosphorylation PhosphoSitePlus
Y1119 Phosphorylation PhosphoSitePlus
S1122 Phosphorylation PhosphoSitePlus
T1123 Phosphorylation PhosphoSitePlus
T1164 Phosphorylation PhosphoSitePlus
S1191 Phosphorylation PhosphoSitePlus
S1196 Phosphorylation PhosphoSitePlus
S1211 Phosphorylation PhosphoSitePlus
S1250 Phosphorylation PhosphoSitePlus
S1283 Phosphorylation PhosphoSitePlus
T1331 Phosphorylation PhosphoSitePlus
S1344 Phosphorylation PhosphoSitePlus
R1437 Methylation PhosphoSitePlus
Y1443 Phosphorylation PhosphoSitePlus
S1535 Phosphorylation PhosphoSitePlus
T1586 Phosphorylation PhosphoSitePlus
S1587 Phosphorylation PhosphoSitePlus
S1630 Phosphorylation PhosphoSitePlus
S1642 Phosphorylation PhosphoSitePlus
S1691 Phosphorylation PhosphoSitePlus
S1703 Phosphorylation PhosphoSitePlus
S1762 Phosphorylation PhosphoSitePlus
Y1767 Phosphorylation PhosphoSitePlus
S1770 Phosphorylation PhosphoSitePlus
T1771 Phosphorylation PhosphoSitePlus
T1812 Phosphorylation PhosphoSitePlus
S1827 Phosphorylation PhosphoSitePlus
S1894 Phosphorylation PhosphoSitePlus
S1895 Phosphorylation PhosphoSitePlus
S1919 Phosphorylation PhosphoSitePlus
S1922 Phosphorylation PhosphoSitePlus
S1954 Phosphorylation PhosphoSitePlus
S1999 Phosphorylation PhosphoSitePlus
S2013 Phosphorylation PhosphoSitePlus
S2034 Phosphorylation PhosphoSitePlus
S2047 Phosphorylation PhosphoSitePlus
R2086 Methylation PhosphoSitePlus
S2087 Phosphorylation PhosphoSitePlus
Y2092 Phosphorylation PhosphoSitePlus
T2137 Phosphorylation PhosphoSitePlus
S2199 Phosphorylation PhosphoSitePlus
S2203 Phosphorylation PhosphoSitePlus
S2208 Phosphorylation PhosphoSitePlus
S2241 Phosphorylation PhosphoSitePlus
S2242 Phosphorylation PhosphoSitePlus
S2247 Phosphorylation PhosphoSitePlus
S2253 Phosphorylation PhosphoSitePlus
S2256 Phosphorylation PhosphoSitePlus
S2260 Phosphorylation PhosphoSitePlus
S2262 Phosphorylation PhosphoSitePlus
S2264 Phosphorylation PhosphoSitePlus
S2270 Phosphorylation PhosphoSitePlus
S2324 Phosphorylation PhosphoSitePlus
S2411 Phosphorylation PhosphoSitePlus
Y2416 Phosphorylation PhosphoSitePlus
S2419 Phosphorylation PhosphoSitePlus
T2420 Phosphorylation PhosphoSitePlus
S2476 Phosphorylation PhosphoSitePlus
S2514 Phosphorylation HPRD   PhosphoSitePlus 17924679
T2517 Phosphorylation HPRD   PhosphoSitePlus 17924679
R2528 Methylation PhosphoSitePlus
S2530 Phosphorylation PhosphoSitePlus
S2538 Phosphorylation PhosphoSitePlus
S2544 Phosphorylation PhosphoSitePlus
T2559 Phosphorylation PhosphoSitePlus
S2560 Phosphorylation PhosphoSitePlus
S2566 Phosphorylation PhosphoSitePlus
S2568 Phosphorylation PhosphoSitePlus
S2571 Phosphorylation PhosphoSitePlus
S2594 Phosphorylation PhosphoSitePlus
S2648 Phosphorylation PhosphoSitePlus
S2737 Phosphorylation PhosphoSitePlus
Y2740 Phosphorylation PhosphoSitePlus
S2851 Phosphorylation PhosphoSitePlus
S2854 Phosphorylation PhosphoSitePlus
S2856 Phosphorylation PhosphoSitePlus
S2889 Phosphorylation PhosphoSitePlus
S2890 Phosphorylation PhosphoSitePlus
S2895 Phosphorylation PhosphoSitePlus
S2901 Phosphorylation PhosphoSitePlus
S2904 Phosphorylation PhosphoSitePlus
S2918 Phosphorylation PhosphoSitePlus
S2972 Phosphorylation PhosphoSitePlus
S3061 Phosphorylation PhosphoSitePlus
Y3064 Phosphorylation PhosphoSitePlus
S3213 Phosphorylation PhosphoSitePlus
S3214 Phosphorylation PhosphoSitePlus
S3219 Phosphorylation PhosphoSitePlus
S3225 Phosphorylation PhosphoSitePlus
S3228 Phosphorylation PhosphoSitePlus
S3251 Phosphorylation PhosphoSitePlus
S3274 Phosphorylation PhosphoSitePlus
T3281 Phosphorylation PhosphoSitePlus
S3282 Phosphorylation PhosphoSitePlus
S3283 Phosphorylation PhosphoSitePlus
S3289 Phosphorylation PhosphoSitePlus
S3290 Phosphorylation PhosphoSitePlus
S3316 Phosphorylation PhosphoSitePlus
S3383 Phosphorylation PhosphoSitePlus
Y3388 Phosphorylation PhosphoSitePlus
S3391 Phosphorylation PhosphoSitePlus
T3392 Phosphorylation PhosphoSitePlus
T3433 Phosphorylation PhosphoSitePlus
S3510 Phosphorylation PhosphoSitePlus
T3511 Phosphorylation PhosphoSitePlus
S3515 Phosphorylation PhosphoSitePlus
S3516 Phosphorylation PhosphoSitePlus
S3540 Phosphorylation PhosphoSitePlus
S3543 Phosphorylation PhosphoSitePlus
S3620 Phosphorylation PhosphoSitePlus
S3707 Phosphorylation PhosphoSitePlus
Y3712 Phosphorylation PhosphoSitePlus
S3715 Phosphorylation PhosphoSitePlus
T3716 Phosphorylation PhosphoSitePlus
S3722 Phosphorylation PhosphoSitePlus
S3737 Phosphorylation PhosphoSitePlus
T3757 Phosphorylation PhosphoSitePlus
S3784 Phosphorylation PhosphoSitePlus
S3789 Phosphorylation PhosphoSitePlus
S3804 Phosphorylation PhosphoSitePlus
T3835 Phosphorylation PhosphoSitePlus
S3843 Phosphorylation PhosphoSitePlus
S3850 Phosphorylation PhosphoSitePlus
S3853 Phosphorylation PhosphoSitePlus
S3861 Phosphorylation PhosphoSitePlus
S3915 Phosphorylation HPRD 18691976
S3938 Phosphorylation PhosphoSitePlus
Y3940 Phosphorylation PhosphoSitePlus
S3952 Phosphorylation PhosphoSitePlus
Y3958 Phosphorylation PhosphoSitePlus
Y3984 Phosphorylation PhosphoSitePlus
Y4001 Phosphorylation PhosphoSitePlus
S4018 Phosphorylation PhosphoSitePlus
Y4031 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y18 * Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S127 N127 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S127 G127 Biomuta DOID:10534 / stomach cancer [ tcga ]
S165 P165 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T167 N167 Biomuta DOID:3571 / liver cancer [ icgc ]
S303 G303 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S314 F314 Biomuta DOID:363 / uterine cancer [ tcga ]
S314 T314 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
S314 Y314 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
S316 L316 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:10534 / stomach cancer [ tcga ]
R343 K343 Biomuta DOID:1909 / melanoma [ tcga ] DOID:11934 / head and neck cancer [ tcga ]
Y470 * Biomuta DOID:3571 / liver cancer [ icgc ]
S535 L535 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ icgc, tcga ]
T581 N581 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T581 A581 Biomuta DOID:1909 / melanoma [ tcga ]
T581 S581 Biomuta DOID:3963 / thyroid carcinoma [ tcga ] DOID:2394 / ovarian cancer [ tcga ] DOID:4362 / cervical cancer [ tcga ] DOID:3571 / liver cancer [ icgc ]
S622 R622 Biomuta DOID:1909 / melanoma [ cosmic ] DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S638 C638 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S642 F642 Biomuta DOID:1909 / melanoma [ tcga ]
S702 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S950 N950 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S956 L956 Biomuta DOID:1612 / breast cancer [ tcga ]
S959 Y959 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:2394 / ovarian cancer [ icgc ]
S1013 F1013 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1014 F1014 Biomuta DOID:1909 / melanoma [ tcga ]
S1020 A1020 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S1055 L1055 Biomuta DOID:1909 / melanoma [ tcga ]
S1114 * Biomuta DOID:11934 / head and neck cancer [ tcga ]
T1164 P1164 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1191 T1191 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1250 * Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1283 Y1283 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1344 L1344 Biomuta DOID:1324 / lung cancer [ cosmic ]
R1437 H1437 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y1443 * Biomuta DOID:3571 / liver cancer [ icgc ]
S1535 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T1586 K1586 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S1642 G1642 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1642 T1642 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S1703 L1703 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y1767 H1767 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1827 Y1827 Biomuta DOID:1324 / lung cancer [ tcga ]
S1894 R1894 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1324 / lung cancer [ cosmic ]
S1919 I1919 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1954 F1954 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S1999 P1999 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S2013 * Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S2013 L2013 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2047 N2047 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3571 / liver cancer [ icgc ] DOID:1324 / lung cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ] DOID:0070003 / blastoma [ cosmic ]
R2086 H2086 Biomuta DOID:3571 / liver cancer [ icgc ]
R2086 C2086 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ]
T2137 P2137 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S2199 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:11934 / head and neck cancer [ tcga ]
S2199 L2199 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S2208 P2208 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S2260 Y2260 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:3070 / malignant glioma [ cosmic ]
S2262 Y2262 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S2270 Y2270 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2324 L2324 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y2416 C2416 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2476 Y2476 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:5041 / esophageal cancer [ tcga ]
S2530 * Biomuta DOID:1324 / lung cancer [ tcga ]
S2538 A2538 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S2560 T2560 Biomuta DOID:1790 / malignant mesothelioma [ tcga ]
S2854 T2854 Biomuta DOID:1324 / lung cancer [ tcga ]
S2854 L2854 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S2854 A2854 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S2856 L2856 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]
S2856 P2856 Biomuta DOID:363 / uterine cancer [ tcga ]
S2889 C2889 Biomuta DOID:1324 / lung cancer [ tcga ]
S2904 Y2904 Biomuta DOID:363 / uterine cancer [ tcga ]
S3213 F3213 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S3225 * Biomuta DOID:3571 / liver cancer [ icgc ]
S3228 C3228 Biomuta DOID:1324 / lung cancer [ tcga ]
T3281 N3281 Biomuta DOID:3571 / liver cancer [ icgc ]
S3283 Y3283 Biomuta DOID:1324 / lung cancer [ cosmic ]
S3283 F3283 Biomuta DOID:1612 / breast cancer [ tcga ]
S3316 * Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y3388 H3388 Biomuta DOID:1324 / lung cancer [ tcga ]
S3391 N3391 Biomuta DOID:1324 / lung cancer [ cosmic ]
S3540 I3540 Biomuta DOID:10534 / stomach cancer [ tcga ]
S3543 N3543 Biomuta DOID:1909 / melanoma [ tcga ] DOID:1324 / lung cancer [ cosmic ]
S3620 L3620 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, tcga ]
S3737 F3737 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S3784 A3784 Biomuta DOID:10534 / stomach cancer [ tcga ]
S3784 P3784 Biomuta DOID:363 / uterine cancer [ tcga ]
T3835 N3835 Biomuta DOID:3571 / liver cancer [ icgc ]
T3835 A3835 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S3850 L3850 Biomuta DOID:363 / uterine cancer [ icgc, tcga ] DOID:1324 / lung cancer [ cosmic ]
S3850 * Biomuta DOID:363 / uterine cancer [ tcga ]
S3861 F3861 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S3915 Y3915 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S3915 C3915 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S3938 Y3938 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y4031 C4031 Biomuta DOID:9256 / colorectal cancer [ tcga ]