iPTMnet Report for P17735 (TAT)
Protein Information
UniProt AC / UniProt ID | P17735 / ATTY_HUMAN |
Protein Name | Tyrosine aminotransferase |
Gene Name | Name: TAT |
Organism | Homo sapiens (Human) |
PRO ID | PR:P17735 |
PRO Name | tyrosine aminotransferase (human) |
Definition | A tyrosine aminotransferase that is encoded in the genome of human. |
Short Label | hTAT |
Category | organism-gene |
P17735 (TAT) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S10 | Phosphorylation | score1 | PhosphoSitePlus | |||
S16 | Phosphorylation | score1 | RLIMS-P | 17083724, 29792216 | ||
K33 | Acetylation | score1 | PhosphoSitePlus | |||
S46 | Phosphorylation | score1 | RLIMS-P | 17083724, 29792216, 8914829 | ||
T321 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y442 | Phosphorylation | score1 | PhosphoSitePlus | |||
S448 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 20166139, 24275569 |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P17735 (TAT) | S16 | O60563 (CCNT1) | decreased_association | eFIP | 29792216 | |
Phosphorylation | P17735 (TAT) | S16 | P50750 (CDK9) | unknown | eFIP | 29792216 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S16 | L16 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
T321 | I321 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] |