Protein Information

Cytoscape View


UniProt AC / UniProt ID P14550 / AK1A1_HUMAN
Protein Name Aldo-keto reductase family 1 member A1
Gene Name Name: AKR1A1
Synonyms:ALDR1,ALR;
Organism Homo sapiens (Human)

PRO ID PR:P14550
DAG View
PRO Name aldo-keto reductase family 1 member A1 (human)
Definition An aldo-keto reductase family 1 member A1 that is encoded in the genome of human.
Short Label hAKR1A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14550 (AKR1A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 25944712
K13 Ubiquitination PhosphoSitePlus
K23 Sumoylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y50 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K127 Acetylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
C134 S-Nitrosylation dbSNO 19483679
S137 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
T208 Phosphorylation HPRD 20068231
Y210 Phosphorylation PhosphoSitePlus
S211 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S215 Phosphorylation HPRD 20068231
S216 Phosphorylation HPRD 20068231
K263 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
T280 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
T304 Phosphorylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
Y325 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K80 * Biomuta DOID:1324 / lung cancer [ tcga ]
K153 E153 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S162 F162 Biomuta DOID:363 / uterine cancer [ tcga ]
S211 I211 Biomuta DOID:3070 / malignant glioma [ cosmic ]
S211 C211 Biomuta DOID:1612 / breast cancer [ tcga ]
S215 C215 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K275 N275 Biomuta DOID:363 / uterine cancer [ tcga ]
T304 M304 Biomuta DOID:3571 / liver cancer [ icgc ]