Protein Information

Cytoscape View

UniProt AC / UniProt ID P14324 / FPPS_HUMAN
Protein Name Farnesyl pyrophosphate synthase
Gene Name Name: FDPS
Organism Homo sapiens (Human)

PRO ID PR:P14324
DAG View
PRO Name farnesyl pyrophosphate synthase (human)
Definition A farnesyl pyrophosphate synthase that is encoded in the genome of human.
Short Label hFDPS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P14324 (FDPS) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K80 Acetylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
Y117 Phosphorylation PhosphoSitePlus
K123 Acetylation PhosphoSitePlus   UniProt 19608861
K123 Ubiquitination PhosphoSitePlus
Y124 Phosphorylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
Y273 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus
Y349 Phosphorylation PhosphoSitePlus
K353 Acetylation PhosphoSitePlus   UniProt 19608861
K353 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036244 (hFDPS/Ac:1) acM1 PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S88 F88 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y124 C124 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y265 C265 Biomuta DOID:363 / uterine cancer [ tcga ]
Y265 F265 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
Y273 H273 Biomuta DOID:2394 / ovarian cancer [ tcga ]
K332 T332 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]