Protein Information

Cytoscape View


UniProt AC / UniProt ID P13797 / PLST_HUMAN
Protein Name Plastin-3
Gene Name Name: PLS3
Organism Homo sapiens (Human)

PRO ID PR:P13797
DAG View
PRO Name plastin-3 (human)
Definition A plastin-3 that is encoded in the genome of human.
Short Label hPLS3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P13797 (PLS3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K11 Ubiquitination PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
Y35 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
R66 Methylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T117 Phosphorylation PhosphoSitePlus
Y121 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
R144 Methylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
K185 Acetylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K297 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K335 Acetylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus   UniProt 24275569
K346 Ubiquitination PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231
K437 Ubiquitination PhosphoSitePlus
K444 Methylation PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K459 Acetylation PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
T492 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
K545 Methylation PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
Y601 Phosphorylation PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
T617 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T117 Phosphorylation HPRD 17525332
S203 Phosphorylation HPRD 18452278
S205 Phosphorylation HPRD 18452278
S268 Phosphorylation HPRD 20068231
S293 Phosphorylation HPRD 19651622, 20068231
S326 Phosphorylation HPRD 18669648, 20068231
S339 Phosphorylation HPRD 20068231
T391 Phosphorylation HPRD 18669648, 20068231
T617 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K85 N85 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K100 T100 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S173 L173 Biomuta DOID:1324 / lung cancer [ tcga ]
K185 N185 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S203 C203 Biomuta DOID:11934 / head and neck cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
K266 N266 Biomuta DOID:3571 / liver cancer [ icgc ]
Y302 H302 Biomuta DOID:5041 / esophageal cancer [ icgc ]
Y302 C302 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S339 I339 Biomuta DOID:0070003 / blastoma [ cosmic ]
K346 T346 Biomuta DOID:363 / uterine cancer [ tcga ]
S360 G360 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K459 N459 Biomuta DOID:363 / uterine cancer [ tcga ]