Protein Information

Cytoscape View


UniProt AC / UniProt ID P13196 / HEM1_HUMAN
Protein Name 5-aminolevulinate synthase, nonspecific, mitochondrial precursor
Gene Name Name: ALAS1
Synonyms:ALAS3,ALASH;ORFNames:OK/SW-cl.121;
Organism Homo sapiens (Human)

PRO ID PR:P13196
DAG View
PRO Name 5-aminolevulinate synthase, nonspecific, mitochondrial (human)
Definition A 5-aminolevulinate synthase, nonspecific, mitochondrial that is encoded in the genome of human.
Short Label hALAS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P13196 (ALAS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K42 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K176 Acetylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K210 Acetylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
T280 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
Y628 Phosphorylation PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T269 Phosphorylation HPRD 18767875


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K168 N168 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K192 T192 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]