Protein Information

Cytoscape View


UniProt AC / UniProt ID P12035 / K2C3_HUMAN
Protein Name Keratin, type II cytoskeletal 3
Gene Name Name: KRT3
Organism Homo sapiens (Human)

PRO ID PR:P12035
DAG View
PRO Name keratin, type II cytoskeletal 3 (human)
Definition A keratin, type II cytoskeletal 3 that is encoded in the genome of human.
Short Label hKRT3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P12035 (KRT3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
R84 Methylation PhosphoSitePlus
R113 Methylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
T204 Phosphorylation PhosphoSitePlus
K208 Acetylation PhosphoSitePlus
K208 Methylation PhosphoSitePlus
K208 Sumoylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
Y393 Phosphorylation PhosphoSitePlus
T395 Phosphorylation PhosphoSitePlus
T402 Phosphorylation PhosphoSitePlus
Y511 Phosphorylation PhosphoSitePlus
Y597 Phosphorylation PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 F17 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S65 N65 Biomuta DOID:1319 / brain cancer [ icgc ] DOID:3070 / malignant glioma [ cosmic ] DOID:11934 / head and neck cancer [ tcga ]
S65 I65 Biomuta DOID:363 / uterine cancer [ tcga ]
R84 W84 Biomuta DOID:0070003 / blastoma [ cosmic ]
R84 Q84 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K215 R215 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S274 F274 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y511 C511 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]