Protein Information

Cytoscape View


UniProt AC / UniProt ID P09936 / UCHL1_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase isozyme L1 precursor
Gene Name Name: UCHL1
Organism Homo sapiens (Human)

PRO ID PR:P09936
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase isozyme L1 (human)
Definition A ubiquitin carboxyl-terminal hydrolase isozyme L1 that is encoded in the genome of human.
Short Label hUCHL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P09936 (UCHL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Acetylation PhosphoSitePlus
K4 Ubiquitination PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
K123 Acetylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
C132 S-Nitrosylation dbSNO 26338901
K135 Ubiquitination PhosphoSitePlus
C152 S-Nitrosylation dbSNO 19483679, 26338901
K157 Ubiquitination PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
S189 Phosphorylation HPRD   PhosphoSitePlus 20068231
T192 Phosphorylation PhosphoSitePlus
K195 Acetylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
T205 Phosphorylation PhosphoSitePlus
C220 S-Nitrosylation dbSNO 19483679, 2212679, 22126794
K221 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K83 T83 Biomuta DOID:363 / uterine cancer [ tcga ]
K135 N135 Biomuta DOID:363 / uterine cancer [ tcga ]
S188 C188 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]