Protein Information

Cytoscape View


UniProt AC / UniProt ID P09110 / THIK_HUMAN
Protein Name 3-ketoacyl-CoA thiolase, peroxisomal precursor
Gene Name Name: ACAA1
Synonyms:ACAA,PTHIO;
Organism Homo sapiens (Human)

PRO ID PR:P09110
DAG View
PRO Name 3-ketoacyl-CoA thiolase, peroxisomal (human)
Definition A 3-ketoacyl-CoA thiolase, peroxisomal that is encoded in the genome of human.
Short Label hACAA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P09110 (ACAA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T59 Phosphorylation PhosphoSitePlus   UniProt 19690332
T60 Phosphorylation PhosphoSitePlus   UniProt 19690332
T70 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
K198 Acetylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K234 Acetylation PhosphoSitePlus
K237 Acetylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
K259 Acetylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
Y323 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus
K395 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S124 L124 Biomuta DOID:1909 / melanoma [ cosmic, icgc, tcga ]
S125 L125 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ] DOID:1324 / lung cancer [ tcga ]
S269 P269 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]