Protein Information

Cytoscape View


UniProt AC / UniProt ID P08581 / MET_HUMAN
Protein Name Hepatocyte growth factor receptor precursor
Gene Name Name: MET
Organism Homo sapiens (Human)

PRO ID PR:P08581
DAG View
PRO Name hepatocyte growth factor receptor (human)
Definition A hepatocyte growth factor receptor that is encoded in the genome of human.
Short Label hMET
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08581 (MET) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T17 Phosphorylation PhosphoSitePlus
N106 N-Glycosylation UniProt 19196183
S178 Phosphorylation RLIMS-P 25778903
K189 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
S473 Phosphorylation RLIMS-P 19240370
S637 Phosphorylation PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
Y745 Phosphorylation PhosphoSitePlus
T750 Phosphorylation PhosphoSitePlus
S755 Phosphorylation PhosphoSitePlus
S758 Phosphorylation PhosphoSitePlus
T759 Phosphorylation PhosphoSitePlus
K765 Ubiquitination PhosphoSitePlus
Y830 Phosphorylation phospho.ELM   PhosphoSitePlus 12746450
K962 Ubiquitination PhosphoSitePlus
S966 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y971 Phosphorylation PhosphoSitePlus
T977 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17192257
S985 Phosphorylation Q02156 (PRKCE) , P17252 (PRKCA) , Q05655 (PRKCD) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 7925482, 8294430, 7765452, ...15075332, 24634221, 27147579
S988 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17192257
S990 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17192257
T992 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T993 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S997 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1000 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y1003 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 19369195, 21283737, ...22973954, 23624790, 17192257, 18083107, 24362531, 19240370, 11741535, 24634221, 24330766
T1006 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus
S1020 Phosphorylation PhosphoSitePlus
Y1026 Phosphorylation PhosphoSitePlus
Y1093 Phosphorylation PhosphoSitePlus
T1096 Phosphorylation PhosphoSitePlus
K1104 Ubiquitination PhosphoSitePlus
Y1159 Phosphorylation PhosphoSitePlus
K1161 Ubiquitination PhosphoSitePlus
K1190 Acetylation PhosphoSitePlus
K1190 Ubiquitination PhosphoSitePlus
K1193 Ubiquitination PhosphoSitePlus
Y1194 Phosphorylation PhosphoSitePlus
K1219 Ubiquitination PhosphoSitePlus
Y1230 Phosphorylation P08581 (MET) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 27191264, 12475979, 21423210, ...20145145, 18083107, 19240370, 20085644
K1232 Ubiquitination PhosphoSitePlus
Y1234 Phosphorylation P08581 (MET) , Q04912 (MST1R) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21992464, 7961992, 20085644, ...16914575, 12475979, 21423210, 22511956, 26801760, 1247597, 28248267, 21247903, 8302603, 24634221, 8547236, 20145145, 26252654, 23968581, 26540318, 25607934, 27323832, 18083107, 24362531, 19240370, 10871856, 8208547, 27147579
Y1235 Phosphorylation P08581 (MET) , Q04912 (MST1R) , P51813 (BMX) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21992464, 22745804, 23716717, ...7961992, 20085644, 16914575, 27191264, 12475979, 21423210, 22511956, 1655790, 26801760, 1247597, 28248267, 21247903, 8302603, 24634221, 8547236, 20145145, 26252654, 23968581, 26540318, 27323832, 7765452, 18083107, 24362531, 19240370, 10871856, 8208547
S1236 Phosphorylation PhosphoSitePlus
K1240 Ubiquitination PhosphoSitePlus
T1241 Phosphorylation PhosphoSitePlus
T1289 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y1307 Phosphorylation PhosphoSitePlus
Y1313 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 10069803, 24634221, 21777671, ...23583448, 7708691
K1318 Ubiquitination PhosphoSitePlus
S1342 Phosphorylation PhosphoSitePlus
T1343 Phosphorylation PhosphoSitePlus
Y1349 Phosphorylation P00519 (ABL1) , Q04912 (MST1R) , P08581 (MET) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26259250, 7513258, 22745804, ...9826708, 18779368, 20432459, 21777671, 16782899, 26436697, 16914575, 19187270, 12475979, 7731718, 21734462, 26215852, 24634221, 18046719, 23583448, 20145145, 9444958, 21283737, 9252406, 27191264, 24362531, 10871856, 7687741
T1355 Phosphorylation PhosphoSitePlus
Y1356 Phosphorylation P00519 (ABL1) , Q04912 (MST1R) , P08581 (MET) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 9444958, 7513258, 7961992, ...7687741, 15735664, 9252406, 9826708, 8547236, 21777671, 23583448, 10871856, 16782899, 12475979, 8662889, 7731718
Y1365 Phosphorylation P08581 (MET) phospho.ELM   PhosphoSitePlus   UniProt 12475979, 20145145
S1367 Phosphorylation PhosphoSitePlus
S1370 Phosphorylation PhosphoSitePlus
S1371 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S966 Phosphorylation HPRD 18691976
T977 Phosphorylation P08581 (MET) HPRD 18691976, 17192257, 20068231
S985 Phosphorylation HPRD 8294430
S988 Phosphorylation P08581 (MET) HPRD 18691976, 18669648, 17192257, ...20068231, 18452278
S990 Phosphorylation P08581 (MET) HPRD 18691976, 18669648, 17192257, ...18452278
T992 Phosphorylation HPRD 18669648
T993 Phosphorylation HPRD 18669648
S997 Phosphorylation HPRD 18691976, 18669648
S1000 Phosphorylation HPRD 18691976, 18669648, 17081983
Y1003 Phosphorylation HPRD 18691976, 11741535
Y1230 Phosphorylation HPRD 17016520, 12475979
Y1234 Phosphorylation HPRD 17016520, 8302603, 7961992
Y1235 Phosphorylation HPRD 12475979
Y1295 Phosphorylation HPRD 10069803, 7708691
S1331 Phosphorylation HPRD 12475979, 9444958, 7731718, ...7513258, 9252406
S1338 Phosphorylation HPRD 12475979, 9444958, 7731718, ...7513258, 9252406
Y1349 Phosphorylation HPRD 10069803, 12475979, 7708691
Y1356 Phosphorylation HPRD 10069803, 7961992, 7708691
Y1365 Phosphorylation HPRD 12475979


P08581 (MET) as PTM Enzyme



Substrate Site Score Source PMID
P08581-1 (MET) T977 HPRD 18691976, 17192257, 20068231
P08581-1 (MET) S988 HPRD 18691976, 18669648, 17192257, ...20068231, 18452278
P08581-1 (MET) S990 HPRD 18691976, 18669648, 17192257, ...18452278
P08581 (MET) Y1230 phospho.ELM   PhosphoSitePlus 12475979, 20145145
P08581 (MET) Y1234 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 1247597, 12475979, 8302603, ...20145145, 8547236, 7961992, 8208547
P08581 (MET) Y1235 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 12475979, 8302603, 20145145, ...8547236, 7961992, 1655790, 8208547
P08581 (MET) Y1349 neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 16782899, 7687741, 12475979, ...7731718, 20145145
P08581 (MET) Y1356 neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 15735664, 7687741, 8547236, ...7961992, 16782899, 7731718
P08581 (MET) Y1365 PhosphoSitePlus 20145145
P09874 (PARP1) Y907 PhosphoSitePlus 26779812
P29353 (SHC1) Y427 neXtProt   PhosphoSitePlus 7731718
Q04912 (MST1R) Y1238 PhosphoSitePlus 10871856
Q04912 (MST1R) Y1239 PhosphoSitePlus 10871856
Q04912 (MST1R) Y1353 PhosphoSitePlus 10871856
Q04912 (MST1R) Y1360 PhosphoSitePlus 10871856
Q05397 (PTK2) Y5 neXtProt   PhosphoSitePlus 20802513
Q05397 (PTK2) Y194 neXtProt   PhosphoSitePlus   Signor 16782899, 20802513
Q05397 (PTK2) Y397 neXtProt   PhosphoSitePlus   Signor 16782899
Q05397 (PTK2) Y407 neXtProt   PhosphoSitePlus   Signor 16782899
Q05397 (PTK2) Y576 neXtProt   PhosphoSitePlus   Signor 16782899
Q05397 (PTK2) Y577 neXtProt   PhosphoSitePlus   Signor 16782899
Q05397 (PTK2) Y861 neXtProt   PhosphoSitePlus   Signor 16782899
Q05397 (PTK2) Y925 neXtProt   PhosphoSitePlus   Signor 16782899
Q13480-1 (GAB1) Y285 HPRD   neXtProt   phospho.ELM   Signor 10734310
Q13480 (GAB1) Y307 HPRD   neXtProt   phospho.ELM 10734310, 16497976
Q13480 (GAB1) Y373 HPRD   neXtProt   phospho.ELM 10978177, 10734310, 17389395, ...16497976
Q13480-1 (GAB1) Y406 HPRD   neXtProt   phospho.ELM 17016520, 10734310, 17389395, ...19901323, 16497976
Q13480-2 (GAB1) Y447 HPRD   neXtProt   phospho.ELM 10734310
Q13480-2 (GAB1) Y472 HPRD   neXtProt   phospho.ELM 10734310
Q13480 (GAB1) Y589 HPRD   neXtProt   phospho.ELM   Signor 10734310
Q13480-2 (GAB1) Y619 HPRD 10734310
Q13480-1 (GAB1) Y627 HPRD   neXtProt   phospho.ELM   Signor 17016520, 10734310, 17389395, ...20068231
Q13480-2 (GAB1) Y657 HPRD 17016520, 10734310, 17389395, ...20068231
Q13480-1 (GAB1) Y659 HPRD   neXtProt   phospho.ELM   Signor 10734310, 18669648, 17389395, ...16497976
Q13480-2 (GAB1) Y689 HPRD 10734310, 18669648, 17389395, ...16497976
Q96BD6 (SPSB1) Y31 UniProt 15713673


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P08581 (MET) Y1349 Q13480 (GAB1) increased_association eFIP 18046719