Protein Information

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UniProt AC / UniProt ID P06748 / NPM_HUMAN
Protein Name Nucleophosmin
Gene Name Name: NPM1
Synonyms:NPM;
Organism Homo sapiens (Human)

PRO ID PR:P06748
DAG View
PRO Name nucleophosmin (human)
Definition A nucleophosmin that is encoded in the genome of human.
Short Label hNPM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06748 (NPM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 21406692, 22223895, ...20068231
S4 Phosphorylation P34947 (GRK5) , Q9NYY3 (PLK2) , Q9H4B4 (PLK3) , P53350 (PLK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 21406692, 15190079, 17081983, ...20352051, 27619510, 20962268, 30453269, 23186163, 20068231, 22467873
S10 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
Y17 Phosphorylation PhosphoSitePlus
K24 Acetylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
K27 Acetylation PhosphoSitePlus
K27 Sumoylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
Y29 Phosphorylation PhosphoSitePlus
K32 Acetylation PhosphoSitePlus   UniProt 19608861
K32 Sumoylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus   UniProt 23186163
R45 Methylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
K54 Acetylation PhosphoSitePlus
K54 Sumoylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
Y67 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S70 Phosphorylation P24941 (CDK2) , P51955 (NEK2) , P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 21406692, 17287340, ...17081983, 23851489, 18220336, 20962268, 18847512, 18234856, 16565220, 18669648, 24275569, 23186163, 19933706, 19690332, 20068231, 17924679
K73 Sumoylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
T75 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T78 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K80 Ubiquitination PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
T86 Phosphorylation PhosphoSitePlus
S88 Phosphorylation P51955 (NEK2) phospho.ELM   PhosphoSitePlus 23851489, 18220336
T95 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16041368, 23186163, 17081983, ...18220336, 18669648, 20068231
R101 Methylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S125 Phosphorylation O14965 (AURKA) , Q13535 (ATR) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 19369195, 21406692, 23186163, ...17081983, 18691976, 20962268, 18220336, 30453269, 18318008, 15082766, 18669648, 17287340, 3944116, 29806702, 19690332, 20068231, 24857377
S137 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17287340, 20068231
S139 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K141 Acetylation PhosphoSitePlus
K141 Methylation PhosphoSitePlus
K141 Sumoylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
K150 Acetylation PhosphoSitePlus   UniProt 16916647, 19608861
K150 Sumoylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K154 Acetylation PhosphoSitePlus   UniProt 16916647
K155 Acetylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
R197 Methylation PhosphoSitePlus
T199 Phosphorylation P41279 (MAP3K8) , Q00534 (CDK6) , P24941 (CDK2) , P06493 (CDK1) , P11802 (CDK4) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21242972, 26993766, 15190079, ...30453269, 18454140, 25918010, 18165222, 16912078, 20333249, 31330844, 26123729, 20962268, 11278991, 7213797, 27619510, 24998852, 20713529, 16083285, 17287340, 17081983, 18243139, 26536659, 28045037, 12058066, 17015463, 16376875, 25531824, 24106084, 19933848, 20068231, 17924679
K202 Sumoylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
K212 Acetylation PhosphoSitePlus   UniProt 16916647, 16107701
S214 Phosphorylation PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
K215 Sumoylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
T219 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 12058066, 24106084
S222 Phosphorylation PhosphoSitePlus
K223 Acetylation PhosphoSitePlus
K223 Methylation PhosphoSitePlus
K223 Sumoylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
S227 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 1446684
K229 Acetylation PhosphoSitePlus   UniProt 16107701
K229 Sumoylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
K230 Acetylation PhosphoSitePlus   UniProt 16107701
K230 Sumoylation PhosphoSitePlus
T234 Phosphorylation P24941 (CDK2) , P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 14670079, 20962268, ...30453269, 26536659, 12058066, 18669648, 11278991, 17287340, 24106084, 26993766, 16912078
T237 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26993766, 14670079, 20962268, ...18234856, 30453269, 26536659, 12058066, 18669648, 17287340, 24106084, 23186163, 16912078
K239 Sumoylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S243 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 20068231
K248 Acetylation PhosphoSitePlus
K248 Methylation PhosphoSitePlus
K248 Sumoylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
K250 Acetylation PhosphoSitePlus   UniProt 16107701
K250 Sumoylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
S254 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...16565220, 18669648, 17924679
K257 Acetylation PhosphoSitePlus   UniProt 19608861, 16107701
K257 Sumoylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
S260 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 17287340, ...20068231
K263 Sumoylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
K267 Acetylation PhosphoSitePlus   UniProt 19608861
K267 Sumoylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
K273 Acetylation PhosphoSitePlus   UniProt 19608861
K273 Methylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
T279 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 18220336
K292 Acetylation PhosphoSitePlus   UniProt 16107701
K292 Sumoylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
S4 Phosphorylation P53350 (PLK1) HPRD 19413330, 19651622, 15190079, ...20068231
S10 Phosphorylation HPRD 19413330, 17081983, 19007248, ...18452278, 19651622, 20068231
Y17 Phosphorylation HPRD 19651622, 20068231
S43 Phosphorylation HPRD 18452278
T46 Phosphorylation HPRD 20068231
Y67 Phosphorylation HPRD 19651622, 18452278, 19415658, ...20068231, 17081983
S70 Phosphorylation HPRD 18691976, 17287340, 20230923, ...18767875, 19007248, 18452278, 19651622, 16565220, 19415658, 20068231, 17924679
T75 Phosphorylation HPRD 17924679, 18452278
T78 Phosphorylation HPRD 18452278
S88 Phosphorylation HPRD 18452278
T95 Phosphorylation HPRD 17081983, 20068231, 17924679
S106 Phosphorylation HPRD 20068231, 20230923
S112 Phosphorylation HPRD 20230923
S125 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17287340, 20230923, 19562805, 20058876, 19007248, 18452278, 17322306, 20166139, 20068231
S137 Phosphorylation HPRD 18767875, 17287340, 19664995, ...20068231, 17924679
S139 Phosphorylation HPRD 19413330, 20068231
S195 Phosphorylation HPRD 18691976
T199 Phosphorylation P24941 (CDK2) HPRD 17287340, 18212344, 19651622, ...11278991, 20068231, 17924679
S217 Phosphorylation HPRD 20068231
S218 Phosphorylation HPRD 20068231
T219 Phosphorylation P06493 (CDK1) HPRD 12058066, 20068231
S222 Phosphorylation HPRD 20068231
S227 Phosphorylation HPRD 93076812, 20068231
T234 Phosphorylation P06493 (CDK1) HPRD 11278991, 17287340, 20068231
T237 Phosphorylation P06493 (CDK1) HPRD 11278991, 17287340, 20068231
S242 Phosphorylation HPRD 20068231
S243 Phosphorylation HPRD 19651622, 19415658, 19691289, ...20068231, 19007248
S254 Phosphorylation HPRD 18691976, 19691289, 19007248, ...16565220, 17924679, 19415658, 20068231, 20068230
S260 Phosphorylation HPRD 17287340, 19691289, 19007248, ...19415658, 20068231, 17924679
T279 Phosphorylation HPRD 20068231, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation P53350 (PLK1) HPRD 19413330, 19651622, 15190079, ...20068231
S10 Phosphorylation HPRD 19413330, 17081983, 19007248, ...18452278, 19651622, 20068231
Y17 Phosphorylation HPRD 19651622, 20068231
Y29 Phosphorylation PhosphoSitePlus
S43 Phosphorylation HPRD 18452278
T46 Phosphorylation HPRD 20068231
Y67 Phosphorylation HPRD   phospho.ELM 17081983, 18452278, 19651622, ...18669648, 19415658, 20068231
S70 Phosphorylation HPRD   phospho.ELM 18691976, 17287340, 20230923, ...18767875, 18220336, 19007248, 18452278, 19651622, 18669648, 16565220, 19415658, 20068231, 17924679
T75 Phosphorylation HPRD   phospho.ELM 18669648, 17924679, 18452278
T78 Phosphorylation HPRD   phospho.ELM 18669648, 18452278
S88 Phosphorylation HPRD   phospho.ELM 18220336, 18452278
T95 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 18220336, 18669648, ...20068231, 17924679
S106 Phosphorylation HPRD 20068231, 20230923
S112 Phosphorylation HPRD 20230923
S125 Phosphorylation HPRD   phospho.ELM 19413330, 18691976, 18491316, ...17287340, 18220336, 19562805, 20230923, 20058876, 19007248, 18452278, 17322306, 18669648, 20166139, 20068231
S137 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 18767875, 19664995, ...18669648, 20068231, 17924679
S139 Phosphorylation HPRD   phospho.ELM 19413330, 18669648, 20068231
K141 Acetylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
K150 Acetylation PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
K155 Acetylation PhosphoSitePlus
S198 Phosphorylation HPRD   PhosphoSitePlus 93076812, 20068231
K200 Acetylation PhosphoSitePlus
T205 Phosphorylation P06493 (CDK1) HPRD 11278991, 17287340, 20068231
T208 Phosphorylation P06493 (CDK1) HPRD   PhosphoSitePlus 11278991, 17287340, 20068231
S213 Phosphorylation HPRD 20068231
S214 Phosphorylation HPRD 19651622, 19415658, 19691289, ...20068231, 19007248
S225 Phosphorylation HPRD 18691976, 19691289, 19007248, ...16565220, 17924679, 19415658, 20068231, 20068230
S231 Phosphorylation HPRD 17287340, 19691289, 19007248, ...19415658, 20068231, 17924679
K238 Acetylation PhosphoSitePlus
T250 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231
S10 Phosphorylation HPRD 19413330, 17081983, 19007248, ...18452278, 19651622, 20068231
Y17 Phosphorylation HPRD 19651622, 20068231
S43 Phosphorylation HPRD 18452278
T46 Phosphorylation HPRD 20068231
Y67 Phosphorylation HPRD 19651622, 18452278, 19415658, ...20068231, 17081983
S70 Phosphorylation HPRD 18691976, 17287340, 20230923, ...18767875, 19007248, 18452278, 19651622, 17322306, 19415658, 20068231, 17924679
T75 Phosphorylation HPRD 17924679, 18452278
T78 Phosphorylation HPRD 18452278
S88 Phosphorylation HPRD 18452278
T95 Phosphorylation HPRD 17081983, 20068231, 17924679
S106 Phosphorylation HPRD 20068231, 20230923
S112 Phosphorylation HPRD 20230923
S125 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17287340, 20230923, 19562805, 20058876, 19007248, 18452278, 17322306, 20166139, 20068231
S137 Phosphorylation HPRD 18767875, 17287340, 19664995, ...20068231, 17924679
S139 Phosphorylation HPRD 19413330, 20068231
S195 Phosphorylation HPRD 18691976
T199 Phosphorylation HPRD   neXtProt 12058066, 17287340, 18212344, ...19651622, 20068231, 17924679
S217 Phosphorylation HPRD 20068231
S218 Phosphorylation HPRD 20068231
T219 Phosphorylation HPRD   neXtProt 12058066, 20068231
S222 Phosphorylation HPRD 20068231
S227 Phosphorylation HPRD 20068231
T234 Phosphorylation HPRD   neXtProt 12058066, 17287340, 20068231
T237 Phosphorylation HPRD   neXtProt 12058066, 17287340, 20068231
S242 Phosphorylation HPRD 20068231
S243 Phosphorylation HPRD 19651622, 19415658, 19691289, ...20068231, 19007248
S254 Phosphorylation HPRD   PhosphoSitePlus 18691976, 19691289, 19007248, ...17322306, 19415658, 20068231, 20068230
K257 Acetylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048628 (hNPM1/Phos:2) pS4 PRO
PR:000036307 (hNPM1/Ac:1) acM1 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P06748 (NPM1) T199 O75116 (ROCK2) increased_association eFIP 26536659
Phosphorylation P06748 (NPM1) T199 Q9QR71 (LANA1) unknown eFIP 20333249


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 I1 Biomuta DOID:3571 / liver cancer [ icgc ]
S4 L4 Biomuta DOID:1909 / melanoma [ tcga ]
K27 N27 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
Y29 D29 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K32 E32 Biomuta DOID:3070 / malignant glioma [ tcga ]
S43 Y43 Biomuta DOID:363 / uterine cancer [ tcga ]
K54 R54 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y67 D67 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K73 Q73 Biomuta DOID:1909 / melanoma [ tcga ]
S88 F88 Biomuta DOID:4159 / skin cancer [ icgc ]
S106 L106 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S106 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S112 I112 Biomuta DOID:3571 / liver cancer [ icgc ]
R197 G197 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R197 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:3070 / malignant glioma [ tcga ] DOID:0070003 / blastoma [ cosmic ]
S207 * Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K239 N239 Biomuta DOID:363 / uterine cancer [ tcga ]
S254 I254 Biomuta DOID:3571 / liver cancer [ icgc ]
K257 E257 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S260 P260 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S260 A260 Biomuta DOID:363 / uterine cancer [ tcga ]
S260 C260 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K263 R263 Biomuta DOID:2531 / hematologic cancer [ tcga ]
K273 N273 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, tcga ]
K292 E292 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]