Protein Information

Cytoscape View


UniProt AC / UniProt ID P05231 / IL6_HUMAN
Protein Name Interleukin-6 precursor
Gene Name Name: IL6
Synonyms:IFNB2;
Organism Homo sapiens (Human)

PRO ID PR:P05231
DAG View
PRO Name interleukin-6 (human)
Definition An interleukin-6 that is encoded in the genome of human.
Short Label hIL6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05231 (IL6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N73 N-Glycosylation UniProt 1883960
S81 Phosphorylation HPRD   UniProt 26091039, 1610348
K94 Ubiquitination PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P40763 (STAT3) Y705 P05231 (IL6) unknown eFIP 22280969


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K94 N94 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]