Protein Information

Cytoscape View


UniProt AC / UniProt ID P05165 / PCCA_HUMAN
Protein Name Propionyl-CoA carboxylase alpha chain, mitochondrial precursor
Gene Name Name: PCCA
Organism Homo sapiens (Human)

PRO ID PR:P05165
DAG View
PRO Name propionyl-CoA carboxylase alpha chain, mitochondrial (human)
Definition A propionyl-CoA carboxylase alpha chain, mitochondrial that is encoded in the genome of human.
Short Label hPCCA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05165 (PCCA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
K342 Acetylation PhosphoSitePlus
K343 Acetylation PhosphoSitePlus
Y346 Phosphorylation PhosphoSitePlus
Y401 Phosphorylation PhosphoSitePlus
Y406 Phosphorylation PhosphoSitePlus
K464 Acetylation PhosphoSitePlus
Y473 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
K513 Acetylation PhosphoSitePlus
K519 Acetylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
K553 Acetylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T632 Phosphorylation HPRD 20068231
Y634 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K88 Q88 Biomuta DOID:0070003 / blastoma [ cosmic ]
K88 N88 Biomuta DOID:363 / uterine cancer [ tcga ]
Y143 C143 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K328 T328 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K343 N343 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]
Y401 N401 Biomuta DOID:1324 / lung cancer [ tcga ]
K513 R513 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K519 M519 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S562 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S562 L562 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]