Protein Information

Cytoscape View


UniProt AC / UniProt ID P02549 / SPTA1_HUMAN
Protein Name Spectrin alpha chain, erythrocytic 1
Gene Name Name: SPTA1
Synonyms:SPTA;
Organism Homo sapiens (Human)

PRO ID PR:P02549
DAG View
PRO Name spectrin alpha chain, erythrocytic 1 (human)
Definition A spectrin alpha chain, erythrocytic 1 that is encoded in the genome of human.
Short Label hSPTA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02549 (SPTA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation PhosphoSitePlus
K59 Acetylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
K283 Acetylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
Y370 Phosphorylation PhosphoSitePlus
Y422 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
Y548 Phosphorylation PhosphoSitePlus
Y588 Phosphorylation PhosphoSitePlus
T635 Phosphorylation PhosphoSitePlus
T812 Phosphorylation PhosphoSitePlus
S818 Phosphorylation PhosphoSitePlus
S844 O-Glycosylation GlyGen   PhosphoSitePlus 18984734
Y986 Phosphorylation PhosphoSitePlus
S992 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1064 Phosphorylation PhosphoSitePlus
S1167 Phosphorylation PhosphoSitePlus
S1250 O-Glycosylation GlyGen   PhosphoSitePlus 18984734
T1257 Phosphorylation PhosphoSitePlus
S1284 Phosphorylation PhosphoSitePlus
S1363 Phosphorylation PhosphoSitePlus
S1424 Phosphorylation PhosphoSitePlus
S1425 Phosphorylation PhosphoSitePlus
S1428 Phosphorylation PhosphoSitePlus
K1486 Ubiquitination PhosphoSitePlus
Y1499 Phosphorylation PhosphoSitePlus
Y1538 Phosphorylation PhosphoSitePlus
K1579 Acetylation PhosphoSitePlus
K1586 Acetylation PhosphoSitePlus
S1737 O-Glycosylation GlyGen 18984734
S1738 O-Glycosylation GlyGen   PhosphoSitePlus 18984734
K1803 Ubiquitination PhosphoSitePlus
S1901 Phosphorylation PhosphoSitePlus
T1910 Phosphorylation PhosphoSitePlus
S1912 Phosphorylation PhosphoSitePlus
S1976 Phosphorylation PhosphoSitePlus   UniProt 23186163
K2051 Acetylation PhosphoSitePlus
K2200 Acetylation PhosphoSitePlus
S2269 Phosphorylation PhosphoSitePlus
T2288 Phosphorylation PhosphoSitePlus
Y2333 Phosphorylation PhosphoSitePlus
S2335 Phosphorylation PhosphoSitePlus
S2405 Phosphorylation PhosphoSitePlus
Y2407 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S317 Phosphorylation HPRD 19664994
S507 Phosphorylation HPRD 18452278
T635 Phosphorylation HPRD 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S37 R37 Biomuta DOID:363 / uterine cancer [ tcga ]
S37 T37 Biomuta DOID:1324 / lung cancer [ cosmic ]
S261 C261 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S507 T507 Biomuta DOID:1324 / lung cancer [ tcga ]
Y588 C588 Biomuta DOID:0070003 / blastoma [ cosmic ]
Y588 F588 Biomuta DOID:1324 / lung cancer [ tcga ]
S844 N844 Biomuta DOID:1324 / lung cancer [ tcga ]
S844 R844 Biomuta DOID:363 / uterine cancer [ tcga ]
S992 R992 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1064 * Biomuta DOID:363 / uterine cancer [ tcga ]
S1250 R1250 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S1250 G1250 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S1284 N1284 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S1284 G1284 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1425 F1425 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ icgc, tcga ]
Y1499 H1499 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K1803 N1803 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1901 F1901 Biomuta DOID:1909 / melanoma [ tcga ]
T1910 N1910 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1976 I1976 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K2200 I2200 Biomuta DOID:1612 / breast cancer [ icgc ]
Y2333 * Biomuta DOID:1612 / breast cancer [ tcga ]
S2405 F2405 Biomuta DOID:1909 / melanoma [ tcga ]
S2405 Y2405 Biomuta DOID:1612 / breast cancer [ tcga ]
Y2407 C2407 Biomuta DOID:363 / uterine cancer [ tcga ]