Protein Information

Cytoscape View


UniProt AC / UniProt ID P01009 / A1AT_HUMAN
Protein Name Alpha-1-antitrypsin precursor
Gene Name Name: SERPINA1
Synonyms:AAT,PI;ORFNames:PRO0684,PRO2209;
Organism Homo sapiens (Human)

PRO ID PR:P01009
DAG View
PRO Name alpha-1-antitrypsin (human)
Definition An alpha-1-antitrypsin that is encoded in the genome of human.
Short Label hSERPINA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01009 (SERPINA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T35 Phosphorylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus   UniProt 26091039
N70 N-Glycosylation UniProt 16335952, 15084671, 16622833, ...19159218, 14760718, 22171320, 16263699, 19838169, 12754519
N107 N-Glycosylation UniProt 16335952, 19139490, 19838169, ...16622833, 19159218
K153 Acetylation PhosphoSitePlus
K159 Acetylation PhosphoSitePlus
K160 Acetylation PhosphoSitePlus
Y184 Phosphorylation PhosphoSitePlus
K198 Acetylation PhosphoSitePlus
C256 S-Nitrosylation dbSNO 25040305, 22178444, 10673391
K257 Acetylation PhosphoSitePlus
K258 Acetylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
N271 N-Glycosylation UniProt 16335952, 16622833, 19159218, ...14760718, 22171320, 15084671, 19139490, 19838169, 12754519
K298 Acetylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
K314 Acetylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
T318 Phosphorylation PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus   UniProt 24275569
T416 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T333 Phosphorylation HPRD 20068231
S383 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K153 T153 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K159 N159 Biomuta DOID:363 / uterine cancer [ tcga ]
K160 N160 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
Y184 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K298 N298 Biomuta DOID:1909 / melanoma [ cosmic ]
Y321 N321 Biomuta DOID:1909 / melanoma [ cosmic ]
S383 Y383 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T416 P416 Biomuta DOID:2394 / ovarian cancer [ tcga ]