Protein Information

Cytoscape View


UniProt AC / UniProt ID O75369 / FLNB_HUMAN
Protein Name Filamin-B
Gene Name Name: FLNB
Synonyms:FLN1L,FLN3,TABP,TAP;
Organism Homo sapiens (Human)

PRO ID PR:O75369
DAG View
PRO Name filamin-B (human)
Definition A filamin-B that is encoded in the genome of human.
Short Label hFLNB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75369 (FLNB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Ubiquitination PhosphoSitePlus
K15 Acetylation PhosphoSitePlus
K15 Methylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
R36 Methylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K65 Acetylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
K142 Acetylation PhosphoSitePlus
K169 Acetylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T216 Phosphorylation PhosphoSitePlus   UniProt 24275569
K249 Ubiquitination PhosphoSitePlus
R262 Methylation PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
Y376 Phosphorylation PhosphoSitePlus
T401 O-Glycosylation GlyGen 23301498, 30444036, 30397120, ...26853435, 29351928, 32119511
T436 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
C450 S-Nitrosylation dbSNO 2212679, 22126794
T472 Phosphorylation PhosphoSitePlus
T473 Phosphorylation PhosphoSitePlus
K476 Acetylation PhosphoSitePlus
K480 Acetylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
K492 Acetylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
K502 Acetylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
Y515 Phosphorylation PhosphoSitePlus
S518 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T519 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T528 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
S567 Phosphorylation phospho.ELM 15302935
Y596 Phosphorylation PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
C604 S-Nitrosylation dbSNO 19483679
K607 Ubiquitination PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
Y632 Phosphorylation PhosphoSitePlus
T640 Phosphorylation PhosphoSitePlus
Y651 Phosphorylation PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
S658 Phosphorylation PhosphoSitePlus
C660 S-Nitrosylation dbSNO 19483679
K677 Acetylation PhosphoSitePlus
K681 Acetylation PhosphoSitePlus   UniProt 19608861
K681 Ubiquitination PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
Y704 Phosphorylation PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
Y708 Phosphorylation PhosphoSitePlus
T709 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus   UniProt 20068231
Y732 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S740 Phosphorylation PhosphoSitePlus
K746 Ubiquitination PhosphoSitePlus
S755 Phosphorylation PhosphoSitePlus
C769 S-Nitrosylation dbSNO 26338901
S789 Phosphorylation PhosphoSitePlus
S827 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
S886 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
Y902 Phosphorylation PhosphoSitePlus
Y904 Phosphorylation PhosphoSitePlus
T907 Phosphorylation PhosphoSitePlus
T911 Phosphorylation PhosphoSitePlus
S932 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S945 Phosphorylation PhosphoSitePlus
K946 Acetylation PhosphoSitePlus
R955 Methylation PhosphoSitePlus
K960 Ubiquitination PhosphoSitePlus
T965 Phosphorylation PhosphoSitePlus
T968 Phosphorylation PhosphoSitePlus
R969 Methylation PhosphoSitePlus
T980 Phosphorylation PhosphoSitePlus
S983 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...19690332, 20068231
S985 Phosphorylation PhosphoSitePlus
T994 Phosphorylation PhosphoSitePlus
T997 Phosphorylation PhosphoSitePlus
Y1020 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1028 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1035 Phosphorylation PhosphoSitePlus
K1057 Ubiquitination PhosphoSitePlus
C1081 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
S1121 Phosphorylation PhosphoSitePlus
K1147 Ubiquitination PhosphoSitePlus
S1172 Phosphorylation PhosphoSitePlus
S1174 Phosphorylation PhosphoSitePlus
S1181 Phosphorylation PhosphoSitePlus
T1189 Phosphorylation PhosphoSitePlus
T1198 Phosphorylation PhosphoSitePlus
T1203 Phosphorylation PhosphoSitePlus
K1221 Ubiquitination PhosphoSitePlus
K1241 Ubiquitination PhosphoSitePlus
T1259 Phosphorylation PhosphoSitePlus
S1277 Phosphorylation PhosphoSitePlus
T1307 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1316 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
C1326 S-Nitrosylation dbSNO 20140087
S1329 Phosphorylation PhosphoSitePlus
S1369 Phosphorylation PhosphoSitePlus
K1372 Ubiquitination PhosphoSitePlus
S1409 Phosphorylation PhosphoSitePlus
K1416 Acetylation PhosphoSitePlus
S1422 O-Glycosylation GlyGen 23301498, 30444036, 30397120, ...26853435, 29351928, 32119511
S1422 Phosphorylation PhosphoSitePlus
S1433 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
R1438 Methylation PhosphoSitePlus
S1442 Phosphorylation PhosphoSitePlus
S1447 Phosphorylation PhosphoSitePlus
S1448 Phosphorylation PhosphoSitePlus
K1449 Ubiquitination PhosphoSitePlus
Y1497 Phosphorylation PhosphoSitePlus
S1505 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K1508 Ubiquitination PhosphoSitePlus
S1528 Phosphorylation PhosphoSitePlus
S1529 Phosphorylation PhosphoSitePlus
Y1530 Phosphorylation PhosphoSitePlus
S1535 Phosphorylation PhosphoSitePlus
Y1576 Phosphorylation PhosphoSitePlus
T1579 Phosphorylation PhosphoSitePlus
T1585 Phosphorylation PhosphoSitePlus
T1593 O-Glycosylation GlyGen 23301498, 30444036, 30397120, ...26853435, 29351928, 32119511
S1602 O-Glycosylation GlyGen 23301498, 30444036, 30397120, ...26853435, 29351928, 32119511
S1602 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T1609 Phosphorylation PhosphoSitePlus
K1616 Acetylation PhosphoSitePlus
C1617 S-Nitrosylation dbSNO 2212679, 22126794
K1641 Acetylation PhosphoSitePlus
K1641 Ubiquitination PhosphoSitePlus
Y1684 Phosphorylation PhosphoSitePlus
Y1687 Phosphorylation PhosphoSitePlus
Y1733 Phosphorylation PhosphoSitePlus
K1757 Ubiquitination PhosphoSitePlus
T1773 Phosphorylation PhosphoSitePlus
K1780 Ubiquitination PhosphoSitePlus
T1783 Phosphorylation PhosphoSitePlus
T1785 Phosphorylation PhosphoSitePlus
T1791 Phosphorylation PhosphoSitePlus
S1810 Phosphorylation PhosphoSitePlus
S1823 Phosphorylation PhosphoSitePlus
S1825 Phosphorylation PhosphoSitePlus
Y1827 Phosphorylation PhosphoSitePlus
Y1833 Phosphorylation PhosphoSitePlus
K1872 Ubiquitination PhosphoSitePlus
T1883 Phosphorylation PhosphoSitePlus
S1889 Phosphorylation PhosphoSitePlus
K1897 Acetylation PhosphoSitePlus
K1897 Ubiquitination PhosphoSitePlus
S1902 Phosphorylation PhosphoSitePlus
T1905 Phosphorylation PhosphoSitePlus
S1912 Phosphorylation PhosphoSitePlus
S1916 Phosphorylation PhosphoSitePlus
K1919 Ubiquitination PhosphoSitePlus
S1922 Phosphorylation PhosphoSitePlus
S1937 Phosphorylation phospho.ELM 15302935
K1943 Ubiquitination PhosphoSitePlus
K1955 Ubiquitination PhosphoSitePlus
S1988 Phosphorylation PhosphoSitePlus
S1991 Phosphorylation PhosphoSitePlus
S1997 Phosphorylation PhosphoSitePlus
R2010 Methylation PhosphoSitePlus
S2013 Phosphorylation PhosphoSitePlus
T2017 Phosphorylation PhosphoSitePlus
S2021 Phosphorylation PhosphoSitePlus
S2036 Phosphorylation PhosphoSitePlus
K2044 Ubiquitination PhosphoSitePlus
K2058 Ubiquitination PhosphoSitePlus
S2060 Phosphorylation PhosphoSitePlus
Y2061 Phosphorylation PhosphoSitePlus
S2083 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T2086 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K2088 Ubiquitination PhosphoSitePlus
K2096 Ubiquitination PhosphoSitePlus
S2098 Phosphorylation PhosphoSitePlus
T2100 Phosphorylation PhosphoSitePlus
T2102 Phosphorylation PhosphoSitePlus
S2107 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
T2110 Phosphorylation PhosphoSitePlus
S2113 Phosphorylation PhosphoSitePlus   UniProt 24275569
S2126 Phosphorylation PhosphoSitePlus
S2130 Phosphorylation PhosphoSitePlus
T2134 Phosphorylation PhosphoSitePlus
S2135 Phosphorylation PhosphoSitePlus
K2150 Ubiquitination PhosphoSitePlus
T2166 Phosphorylation PhosphoSitePlus
S2168 Phosphorylation PhosphoSitePlus
K2170 Acetylation PhosphoSitePlus
K2170 Ubiquitination PhosphoSitePlus
R2172 Methylation PhosphoSitePlus
T2177 Phosphorylation PhosphoSitePlus
S2179 Phosphorylation PhosphoSitePlus
R2197 Methylation PhosphoSitePlus
S2227 Phosphorylation PhosphoSitePlus
T2239 Phosphorylation PhosphoSitePlus
Y2260 Phosphorylation PhosphoSitePlus
S2274 Phosphorylation PhosphoSitePlus
Y2276 Phosphorylation PhosphoSitePlus
T2291 Phosphorylation PhosphoSitePlus
S2294 Phosphorylation PhosphoSitePlus
S2298 Phosphorylation PhosphoSitePlus
S2307 Phosphorylation PhosphoSitePlus
S2325 Phosphorylation PhosphoSitePlus
S2327 Phosphorylation PhosphoSitePlus
S2336 Phosphorylation PhosphoSitePlus
K2342 Acetylation PhosphoSitePlus
K2342 Ubiquitination PhosphoSitePlus
Y2343 Phosphorylation PhosphoSitePlus
S2364 Phosphorylation PhosphoSitePlus
S2369 Phosphorylation PhosphoSitePlus   UniProt 20068231
S2403 Phosphorylation PhosphoSitePlus
T2410 Phosphorylation PhosphoSitePlus
S2418 Phosphorylation PhosphoSitePlus
S2425 Phosphorylation PhosphoSitePlus
T2434 Phosphorylation PhosphoSitePlus
T2443 Phosphorylation PhosphoSitePlus
S2453 Phosphorylation PhosphoSitePlus
S2465 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K2468 Ubiquitination PhosphoSitePlus
T2472 Phosphorylation PhosphoSitePlus
S2478 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S2481 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T2485 Phosphorylation phospho.ELM 18669648
S2487 Phosphorylation PhosphoSitePlus
S2492 Phosphorylation PhosphoSitePlus   UniProt 24275569
T2494 Phosphorylation PhosphoSitePlus
T2500 Phosphorylation PhosphoSitePlus
C2501 S-Nitrosylation dbSNO 26338901
Y2502 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455, 18083107
S2503 Phosphorylation PhosphoSitePlus
S2510 Phosphorylation PhosphoSitePlus
S2517 Phosphorylation PhosphoSitePlus
K2518 Ubiquitination PhosphoSitePlus
S2523 Phosphorylation PhosphoSitePlus
K2524 Acetylation PhosphoSitePlus
K2524 Ubiquitination PhosphoSitePlus
S2531 Phosphorylation PhosphoSitePlus
S2532 Phosphorylation PhosphoSitePlus
C2537 S-Nitrosylation dbSNO 2212679, 22126794
S2542 Phosphorylation PhosphoSitePlus
T2553 Phosphorylation PhosphoSitePlus
T2554 Phosphorylation PhosphoSitePlus
C2556 S-Nitrosylation dbSNO 2212679
N2570 N-Glycosylation GlyGen 29671580
K2576 Acetylation PhosphoSitePlus   UniProt 19608861
K2576 Ubiquitination PhosphoSitePlus
Y2581 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S518 Phosphorylation HPRD 18669648
T519 Phosphorylation HPRD 18669648, 20068231
Y523 Phosphorylation HPRD 20068231
S658 Phosphorylation HPRD 17322306, 18767875
S730 Phosphorylation HPRD 20068231
Y732 Phosphorylation HPRD 18669648
S833 Phosphorylation HPRD 20068231
S886 Phosphorylation HPRD 18669648, 20068231
S932 Phosphorylation HPRD 18669648, 20068231
T980 Phosphorylation HPRD 20068231
S983 Phosphorylation HPRD 18691976, 16964243, 19664994, ...19691289, 19664995, 19651622, 18669648, 19415658, 20068231, 17924679
S985 Phosphorylation HPRD 19651622, 20068231
T994 Phosphorylation HPRD 20068231
Y1020 Phosphorylation HPRD 18669648
S1028 Phosphorylation HPRD 18669648
S1181 Phosphorylation HPRD 18452278
T1189 Phosphorylation HPRD 18452278
S1316 Phosphorylation HPRD 18669648, 20068231, 18452278
S1433 Phosphorylation HPRD 18669648, 20068231
S1442 Phosphorylation HPRD 20068231
T1444 Phosphorylation HPRD 20068231
S1505 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
Y1530 Phosphorylation HPRD 17389395
S1602 Phosphorylation HPRD 18669648
Y2032 Phosphorylation HPRD 18767875
S2083 Phosphorylation HPRD 18669648
T2086 Phosphorylation HPRD 18669648
S2107 Phosphorylation HPRD 20166139, 18669648, 19415658, ...20068231
S2369 Phosphorylation HPRD 20068231, 17924679
T2443 Phosphorylation HPRD 20068231
Y2450 Phosphorylation HPRD 20068231
S2453 Phosphorylation HPRD 20068231
S2465 Phosphorylation HPRD 20068231
S2478 Phosphorylation HPRD 20166139, 18691976, 18669648, ...19664994, 20068231
S2481 Phosphorylation HPRD 18669648, 20068231
T2485 Phosphorylation HPRD 18669648
Y2502 Phosphorylation HPRD 15592455, 18083107
Site PTM Type PTM Enzyme Score Source PMID
T1467 Phosphorylation PhosphoSitePlus
S1469 Phosphorylation PhosphoSitePlus
S1474 Phosphorylation PhosphoSitePlus
K1477 Methylation PhosphoSitePlus
S1480 Phosphorylation PhosphoSitePlus
K1484 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P20963 (CD247) Y72 O75369 (FLNB) unknown eFIP 24502978


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K249 N249 Biomuta DOID:363 / uterine cancer [ tcga ]
S339 C339 Biomuta DOID:1324 / lung cancer [ cosmic ]
T401 I401 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T401 N401 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S440 I440 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K476 T476 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K495 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S630 N630 Biomuta DOID:2394 / ovarian cancer [ tcga ]
C660 F660 Biomuta DOID:3571 / liver cancer [ icgc ]
K681 Q681 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K681 N681 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S707 L707 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y708 H708 Biomuta DOID:363 / uterine cancer [ tcga ]
S827 F827 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y904 C904 Biomuta DOID:363 / uterine cancer [ tcga ]
T907 M907 Biomuta DOID:2994 / germ cell cancer [ tcga ]
S932 N932 Biomuta DOID:363 / uterine cancer [ tcga ]
T997 R997 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S1035 L1035 Biomuta DOID:263 / kidney cancer [ tcga ]
S1121 P1121 Biomuta DOID:4362 / cervical cancer [ tcga ]
T1198 M1198 Biomuta DOID:5041 / esophageal cancer [ tcga ]
T1307 A1307 Biomuta DOID:3070 / malignant glioma [ tcga ]
S1329 F1329 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1329 Y1329 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
S1409 I1409 Biomuta DOID:3571 / liver cancer [ icgc ]
R1438 H1438 Biomuta DOID:1612 / breast cancer [ icgc ] DOID:2994 / germ cell cancer [ tcga ]
T1444 M1444 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S1448 I1448 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1528 I1528 Biomuta DOID:3571 / liver cancer [ icgc ]
S1535 G1535 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S1535 N1535 Biomuta DOID:363 / uterine cancer [ tcga ]
S1602 C1602 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1810 N1810 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S1823 C1823 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S1825 F1825 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T1883 I1883 Biomuta DOID:263 / kidney cancer [ cosmic ]
K1943 E1943 Biomuta DOID:1324 / lung cancer [ tcga ]
S1997 L1997 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:3070 / malignant glioma [ tcga ] DOID:0070003 / blastoma [ cosmic ]
S2083 I2083 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S2179 I2179 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R2197 W2197 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y2260 * Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S2274 R2274 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2325 G2325 Biomuta DOID:10534 / stomach cancer [ tcga ]
S2327 Y2327 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
S2364 I2364 Biomuta DOID:1115 / sarcoma [ tcga ]
S2418 F2418 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K2468 E2468 Biomuta DOID:363 / uterine cancer [ tcga ]
S2487 F2487 Biomuta DOID:1909 / melanoma [ tcga ]
S2492 L2492 Biomuta DOID:3070 / malignant glioma [ tcga ]
S2510 L2510 Biomuta DOID:1909 / melanoma [ tcga ]
S2532 Y2532 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]